Evidence map›Paper›PMID 29342349›Full record

ArticleJournal of the American Chemical Society2018

Membrane Allostery and Unique Hydrophobic Sites Promote Enzyme Substrate Specificity.

Varnavas D Mouchlis, Yuan Chen, J Andrew McCammon, Edward A Dennis

Open access · hybridAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 81 citations in OpenAlex.

  1. Trial
  2. Phospholipases: Where Do We Stand?Methods in molecular biology (Clifton, N.J.) · 2027
    Review
  3. Article
  4. Specificity mechanism of Group VIA calcium-independent phospholipase ABiochimica et biophysica acta. Molecular and cell biology of lipids · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. The mechanism of allosteric regulation of calcium-independent phospholipase AProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Differentiating human phospholipase ABiochimica et biophysica acta. Molecular and cell biology of lipids · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Parasitic nematode secreted phospholipase AFrontiers in immunology · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Varnavas D MouchlisDepartment of Chemistry and Biochemistry and Department of Pharmacology, School of Medicine , University of California , San Diego, La Jolla , California 92093-0601 , United States.ORCID 0000-0002-4235-1867
Yuan ChenDepartment of Chemistry and Biochemistry and Department of Pharmacology, School of Medicine , University of California , San Diego, La Jolla , California 92093-0601 , United States.
J Andrew McCammonDepartment of Chemistry and Biochemistry and Department of Pharmacology, School of Medicine , University of California , San Diego, La Jolla , California 92093-0601 , United States.
Edward A DennisDepartment of Chemistry and Biochemistry and Department of Pharmacology, School of Medicine , University of California , San Diego, La Jolla , California 92093-0601 , United States.
University of California San Diego · US

Funding

THEORY OF BIOMOLECULAR DIFFUSIONR01GM031749 · NIGMS · UNIVERSITY OF HOUSTON · PI HUBER, GARY ALEXANDER, MCCAMMON, JAMES ANDREW · 1985 to 2022
$7.8M
ACTION OF LIPOLYTIC ENZYMESR01GM020501 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DENNIS, EDWARD A · 1985 to 2020
$7.3M
DESIGN OF AMPHIPHILIC PEPTOID ASSEMBLIESF32GM020501 · NIGMS · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI BURKOTH, TIMOTHY S · 2000 to 2002
$75k
Howard Hughes Medical InstituteNIGMS NIH HHS F32 GM020501NIGMS NIH HHS R01 GM020501NIGMS NIH HHS R01 GM031749
6 · The paper itself

Abstract

We demonstrate that lipidomics coupled with molecular dynamics reveal unique phospholipase A

Indexed as

Binding SitesCatalytic DomainHumansHydrolysisHydrophobic and Hydrophilic InteractionsMolecular Dynamics SimulationPhospholipases A2, Calcium-IndependentPhospholipases A2, CytosolicPhospholipases A2, SecretoryPhospholipidsSubstrate SpecificityPhospholipases A2, Calcium-IndependentPhospholipases A2, CytosolicPhospholipases A2, SecretoryPhospholipids

Identifiers

PMID29342349
PMCPMC5846079
OpenAlexW2783558436

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.