ArticleThe Journal of medicine and philosophy2018
Serial Participation and the Ethics of Phase 1 Healthy Volunteer Research.
Article in The Journal of medicine and philosophy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Ethics of Human Embryo Editing via CRISPR-Cas9 Technology: A Systematic Review of Ethical Arguments, Reasons, and Concerns.HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues · 2025Pooled it
- The impact of the COVID-19 pandemic on healthy volunteer motivations: a mixed-methods study of participants in plague vaccine trials in the UK and Uganda.BMC public health · 2026Article
- Pharmacovigilance and bioethics: the importance of a neglected relationship.Frontiers in drug safety and regulation · 2025Review
- What motivates SARS-CoV-2 vaccine trial participants? A pre- and post-participation survey study.Trials · 2024Observational
- Shifting from Equality toward Equity: Addressing Disparities in Research Participation for Clinical Cancer Research.The Journal of clinical ethics · 2024Article
- Ethical Criteria for Improved Human Subject Protections in Phase I Healthy Volunteer Trials.Ethics & human research · 2022Article
- Paying for Fairness? Incentives and Fair Subject Selection.The American journal of bioethics : AJOB · 2021Article
- Speculating on Precarious Income: Finance Cultures and the Risky Strategies of Healthy Volunteers in Clinical Drug Trials.Journal of cultural economy · 2021Article
- Healthy volunteers in US phase I clinical trials: Sociodemographic characteristics and participation over time.PloS one · 2021Article
- Reexamining Ophthalmic Drugs, Safety and Tolerability in Phase 1 Clinical Trials.Therapeutics and clinical risk management · 2021Article
- Clinical trials in low-resource settings: the perspectives of caregivers of paediatric participants from Uganda, Tanzania and Kenya.Tropical medicine & international health : TM & IH · 2019Article
- Qualitative study investigating the underlying motivations of healthy participants in phase I clinical trials.BMJ open · 2019Article
- Association Between Financial Incentives and Participant Deception About Study Eligibility.JAMA network open · 2019Article
- Precarity, clinical labour and graduation from Ebola clinical research in West Africa.Global bioethics = Problemi di bioetica · 2019Article
- Advancing Ethics and Policy for Healthy-Volunteer Research through a Model-Organism Framework.Ethics & human research · 2019Article
- "My Body is One of the Best Commodities": Exploring the Ethics of Commodification in Phase I Healthy Volunteer Clinical Trials.Kennedy Institute of Ethics journal · 2019Article
- Healthy Volunteers' Perceptions of the Benefits of Their Participation in Phase I Clinical Trials.Journal of empirical research on human research ethics : JERHRE · 2018Article
- Captive to the Clinic: Phase I Clinical Trials as Temporal Total Institutions.Sociological inquiry · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Phase 1 healthy volunteer clinical trials-which financially compensate subjects in tests of drug toxicity levels and side effects-appear to place pressure on each joint of the moral framework justifying research. In this article, we review concerns about phase 1 trials as they have been framed in the bioethics literature, including undue inducement and coercion, unjust exploitation, and worries about compromised data validity. We then revisit these concerns in light of the lived experiences of serial participants who are income-dependent on phase 1 trials. We show how participant experiences shift attention from discrete exchanges, behaviors, and events in the research enterprise to the ongoing and dynamic patterns of serial participation in which individual decision-making is embedded in collective social and economic conditions and shaped by institutional policies. We argue in particular for the ethical significance of structurally diminished voluntariness, routine powerlessness in setting the terms of exchange, and incentive structures that may promote pharmaceutical interests but encourage phase 1 healthy volunteers to skirt important rules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.