Evidence map›Paper›PMID 29342250›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2018

Pneumococcal Community-Acquired Pneumonia Detected by Serotype-Specific Urinary Antigen Detection Assays.

Richard G Wunderink, Wesley H Self, Evan J Anderson, Robert Balk, Sherene Fakhran, Daniel Mark Courtney, Chao Qi, Derek J Williams, Yuwei Zhu, Cynthia G Whitney and 5 more

Erratum issued Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07354425 (Pneumococcal Community-Acquired Pneumonia Requiring Hospitalization Among Colombian Adults), which is not on this map. Cited by 37 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 3 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07354425 completednot on this mapstarted 2022, after this paper: background citation

Pneumococcal Community-Acquired Pneumonia Requiring Hospitalization Among Colombian Adults (Pneumo-CAP Colombia)

Typeobservational_patient_registrySponsorUniversidad de la SabanaRan2022 to 2025Enrolled688ConditionsCommunity Acquired Pneumonia (CAP), Pneumococcal Pneumonia
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 59 citations in OpenAlex.

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4 · The record

Corrections and comments

  • Erratum issued
    Erratum.2018 · Abstract corrected
5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Richard G WunderinkNorthwestern University Feinberg School of Medicine, Chicago, Illinois.
Wesley H SelfVanderbilt University Medical Center, Nashville, Tennessee.
Evan J AndersonDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.
Robert BalkRush University Medical Center, Chicago, Illinois.
Sherene FakhranJohn H. Stroger, Jr, Hospital of Cook County, Chicago, Illinois.
Daniel Mark CourtneyNorthwestern University Feinberg School of Medicine, Chicago, Illinois.
Chao QiNorthwestern University Feinberg School of Medicine, Chicago, Illinois.
Derek J WilliamsVanderbilt University Medical Center, Nashville, Tennessee.
Yuwei ZhuVanderbilt University Medical Center, Nashville, Tennessee.
Cynthia G WhitneyCenters for Disease Control and Prevention, Atlanta, Georgia.
Matthew R MooreCenters for Disease Control and Prevention, Atlanta, Georgia.
Anna BramleyCenters for Disease Control and Prevention, Atlanta, Georgia.
Seema JainCenters for Disease Control and Prevention, Atlanta, Georgia.
Kathryn M EdwardsVanderbilt University Medical Center, Nashville, Tennessee.
Carlos G GrijalvaVanderbilt University Medical Center, Nashville, Tennessee.
Centers for Disease Control and Prevention · USVanderbilt University Medical Center · USNorthwestern University · USEmory University · USJohn H. Stroger, Jr. Hospital of Cook County · USRush University Medical Center · USVeterans Health Administration · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Streptococcus pneumoniae is considered the leading bacterial cause of pneumonia in adults. Yet, it was not commonly detected by traditional culture-based and conventional urinary testing in a recent multicenter etiology study of adults hospitalized with community-acquired pneumonia (CAP). We used novel serotype-specific urinary antigen detection (SSUAD) assays to determine whether pneumococcal cases were missed by traditional testing. Methods: We studied adult patients hospitalized with CAP at 5 hospitals in Chicago and Nashville (2010-2012) and enrolled in the Etiology of Pneumonia in the Community (EPIC) study. Traditional diagnostic testing included blood and sputum cultures and conventional urine antigen detection (ie, BinaxNOW). We applied SSUAD assays that target serotypes included in the 13-valent pneumococcal conjugate vaccine (PCV13) to stored residual urine specimens. Results: Among 1736 patients with SSUAD and ≥1 traditional pneumococcal test performed, we identified 169 (9.7%) cases of pneumococcal CAP. Traditional tests identified 93 (5.4%) and SSUAD identified 76 (4.4%) additional cases. Among 14 PCV13-serotype cases identified by culture, SSUAD correctly identified the same serotype in all of them. Cases identified by SSUAD vs traditional tests were similar in most demographic and clinical characteristics, although disease severity and procalcitonin concentration were highest among those with positive blood cultures. The proportion of pneumonia cases caused by serotypes exclusively covered by PCV13 was not significantly different between the first and second July-June study periods (6.4% vs 4.0%). Conclusions: Although restricted to the detection of only 13 serotypes, SSUAD testing substantially increased the detection of pneumococcal pneumonia among adults hospitalized with CAP.

Indexed as

SerogroupAdultAgedAntigens, BacterialCommunity-Acquired InfectionsDiagnostic Tests, RoutineFemaleHumansMaleMiddle AgedPneumococcal InfectionsPneumonia, BacterialUrinalysisAntigens, Bacterial

Identifiers

PMID29342250
PMCPMC5930250
OpenAlexW2783743464

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.