ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2018
Associations of Quadriceps Torque Properties with Muscle Size, Attenuation, and Intramuscular Adipose Tissue in Older Adults.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- The "Mechano-Metabolic-Immune" crosstalk within the skeletal muscle microenvironment: evolution of homeostatic remodeling and quality control mechanisms.Frontiers in immunology · 2026Review
- Associations of CT Muscle Area and Density With Functional Outcomes and Mortality Across Anatomical Regions in Older Men.Journal of the American Geriatrics Society · 2025Article
- Deep Learning Technique for Automatic Segmentation of Proximal Hip Musculoskeletal Tissues From CT Scan Images: A MrOS Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- Review
- Differences in muscle morphology assessed by ultrasound at various muscle regions and their impact on voluntary and involuntary force production.Scientific reports · 2025Article
- Radiomic-based biomarkers: Transforming age and body composition metrics into personalized age-informed indices.Clinical and translational science · 2024Review
- The Presence of Myosteatosis Is Associated with Age, Severity of Liver Disease and Poor Outcome and May Represent a Prodromal Phase of Sarcopenia in Patients with Liver Cirrhosis.Journal of clinical medicine · 2023Article
- Diagnosing sarcopenia and myosteatosis based on chest computed tomography images in healthy Chinese adults.Insights into imaging · 2021Article
- Psoriasis Is Associated With Myosteatosis but Not Sarcopenia: A Case-Control Study.Frontiers in medicine · 2021Article
- Current perspectives on obesity and skeletal muscle contractile function in older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Muscle density discriminates hip fracture better than computed tomography X-ray absorptiometry hip areal bone mineral density.Journal of cachexia, sarcopenia and muscle · 2020Article
- Article
- Age-related fatty infiltration of lumbar paraspinal muscles: a normative reference database study in 516 Chinese females.Quantitative imaging in medicine and surgery · 2020Article
- Cigarette Smoking Is Associated With Lower Quadriceps Cross-sectional Area and Attenuation in Older Adults.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Article
- Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging.Frontiers in physiology · 2020Review
- Early and late rapid torque characteristics and select physiological correlates in middle-aged and older males.PloS one · 2020Article
- Quadriceps Lipid Content Has Sex-Specific Associations With Whole-Muscle, Cellular, and Molecular Contractile Function in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Letter to the Editor: What Is the Most Effective Exercise Intervention to Reduce Intermuscular Adipose Tissue in Older People?Annals of geriatric medicine and research · 2019Article
- Quantitative analysis of skeletal muscle by computed tomography imaging-State of the art.Journal of orthopaedic translation · 2018Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
Abstract
Background: Atrophy and fatty infiltration of muscle with aging are associated with fractures and falls, however, their direct associations with muscle function are not well described. It was hypothesized that participants with lower quadriceps muscle attenuation, area, and greater intramuscular adipose tissue (IMAT) will exhibit slower rates of torque development (RTD) and lower peak knee extension torques. Methods: Data from 4,842 participants (2,041 men, 2,801 women) from the Age Gene/Environment Susceptibility Reykjavik Study (mean age 76 ± 0.1 years) with complete thigh computed tomography and isometric knee testing. Regression models were adjusted for health, behavior, and comorbidities. Muscle attenuation was further adjusted for muscle area and IMAT; muscle area adjusted for IMAT and attenuation; and IMAT adjusted for muscle area and attenuation. Standardized betas (β) indicate association effect sizes. Results: In the fully-adjusted models, attenuation (men β = 0.06, 95% CI: 0.01, 0.11; women β = 0.07, 95% CI: 0.03, 0.11) and muscle area (men β = 0.13, 95% CI: 0.07, 0.19; women β = 0.10, 95% CI: 0.06, 0.15) were associated with knee RTD. Attenuation (men β = 0.12, 95% CI: 0.08, 0.16; women β = 0.12, 95% CI: 0.09, 0.16) and muscle area (men β = 0.38, 95% CI: 0.33, 0.43; women β = 0.33, 95% CI: 0.29, 0.37) were associated with peak torque. Conclusions: These data suggest that muscle attenuation and area are independently associated with RTD and peak torque; and that area and attenuation demonstrate similar contributions to RTD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.