ArticleCerebral cortex (New York, N.Y. : 1991)2019
Rhythmic Spontaneous Activity Mediates the Age-Related Decline in Somatosensory Function.
Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 72 citations in OpenAlex.
- Peripheral Somatosensory Entrainment Modulates the Cross-Frequency Coupling of Movement-Related Theta-Gamma Oscillations.Brain connectivity · 2022Trial
- High-definition transcranial direct current stimulation dissociates fronto-visual theta lateralization during visual selective attention.The Journal of physiology · 2020Trial
- Magnetoencephalography in human neuroscience research: planning, piloting, implementation and quality assurance.Nature protocols · 2026Review
- Structure-function coupling of large-scale cortical networks across the lifespan is spectrally specific.Communications biology · 2026Article
- High-definition tDCS of the motor cortex affects prefrontal and primary motor activity differently in young and older adults.GeroScience · 2026Article
- Hemisphere- and condition-specific alpha oscillations support semantic and spatial cognition in aging.GeroScience · 2026Article
- Adults with Down syndrome display altered entrainment of occipital cortical neurons.Brain communications · 2026Article
- Oscillatory and evoked neural responses underlying gating in the primary somatosensory cortices: Evidence from optically-pumped magnetometry.NeuroImage · 2025Article
- Motor-Related Neural Dynamics are Modulated by Regular Cannabis Use Among People with HIV.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Article
- Relationships Between Spontaneous Alpha Oscillation and Brain Response Amid the Complexity of Brain Adaptation and Spectral Signal Composition.Psychophysiology · 2025Article
- Developmental shifts in testosterone levels are associated with alterations in the neural oscillatory dynamics serving selective attention.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Adults with down syndrome exhibit altered somatosensory cortical inhibition.NeuroImage. Clinical · 2025Article
- Age-related alterations in functional and structural networks in the brain in macaque monkeys.Frontiers in neuroanatomy · 2025Article
- Cannabis- and HIV-related perturbations to the cortical gamma dynamics supporting inhibitory processing.Brain communications · 2025Article
- Aging modulates the impact of cognitive interference subtypes on dynamic connectivity across a distributed motor network.npj aging · 2024Article
- Chronic cannabis use alters the spontaneous and oscillatory gamma dynamics serving cognitive control.Human brain mapping · 2024Article
- Distinct Cortical Correlates of Perception and Motor Function in Balance Control.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Developmentally sensitive multispectral cortical connectivity profiles serving visual selective attention.Developmental cognitive neuroscience · 2024Article
- Theta oscillatory dynamics serving cognitive control index psychosocial distress in youth.Neurobiology of stress · 2024Article
- Healthy aging alters the oscillatory dynamics and fronto-parietal connectivity serving fluid intelligence.Human brain mapping · 2024Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Sensory gating is a neurophysiological process whereby the response to a second stimulus in a pair of identical stimuli is attenuated, and it is thought to reflect the capacity of the CNS to preserve neural resources for behaviorally relevant stimuli. Such gating is observed across multiple sensory modalities and is modulated by age, but the mechanisms involved are not understood. In this study, we examined somatosensory gating in 68 healthy adults using magnetoencephalography (MEG) and advanced oscillatory and time-domain analysis methods. MEG data underwent source reconstruction and peak voxel time series data were extracted to evaluate the dynamics of somatosensory gating, and the impact of spontaneous neural activity immediately preceding the stimulation. We found that gating declined with increasing age and that older adults had significantly reduced gating relative to younger adults, suggesting impaired local inhibitory function. Most importantly, older adults had significantly elevated spontaneous activity preceding the stimulation, and this effect fully mediated the impact of aging on sensory gating. In conclusion, gating in the somatosensory system declines with advancing age and this effect is directly tied to increased spontaneous neural activity in the primary somatosensory cortices, which is likely secondary to age-related declines in local GABA inhibitory function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.