ArticleMedical science monitor : international medical journal of experimental and clinical research2018
Thyroid-Stimulating Hormone Levels Are Positively Associated with Insulin Resistance.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Thyroid Stimulating Hormone Levels Are Related to Fatty Liver Indices Independently of Free Thyroxine: A Cross-Sectional Study.Journal of clinical medicine · 2025Article
- DJ-1-mediated repression of the RNA-binding protein FMRP is predicted to impact known Alzheimer's disease-related protein networks.Journal of Alzheimer's disease : JAD · 2024Article
- Increased FT3/FT4 ratio in a certain range is associated with decreased glycemic variability in patients with type 2 diabetes.Scientific reports · 2024Article
- Thyroid Hormones and Diabetes in Euthyroid Hispanic/Latino Adults of Diverse Backgrounds: HCHS/SOL.Journal of the Endocrine Society · 2024Article
- Association Between Maternal Thyroid Function in Early Pregnancy and Gestational Diabetes: A Prospective Cohort Study.The Journal of clinical endocrinology and metabolism · 2024Article
- Exploring the association between triglyceride-glucose index and thyroid function.European journal of medical research · 2023Article
- Effects of Anterior Pituitary Adenomas' Hormones on Glucose Metabolism and Its Clinical Implications.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Review
- Free triiodothyronine (FT3)-to-free thyroxine (FT4) ratio identified as a risk factor for gestational diabetes in euthyroid pregnant women: insights from a Chinese population cohort study.Frontiers in endocrinology · 2023Article
- A breakthrough-like effect of metformin reduces peripheral resistance to triiodothyronine in euthyroid, non-insulin-resistant, type 2 diabetic patients.Endocrine connections · 2021Article
- Observational
- TSH Combined with TSHR Aggravates Diabetic Peripheral Neuropathy by Promoting Oxidative Stress and Apoptosis in Schwann Cells.Oxidative medicine and cellular longevity · 2021Article
- HbA1c is inversely associated with thyroid cysts in a euthyroid population: A cross-sectional study.PloS one · 2021Article
- Reduction in Thyroid-Stimulating Hormone Correlated with Improved Inflammation Markers in Chinese Patients with Morbid Obesity Undergoing Laparoscopic Sleeve Gastrectomy.Obesity surgery · 2019Article
- Therapeutic Effects of Sleeve Gastrectomy and Ileal Transposition on Type 2 Diabetes in a Non-Obese Rat Model by Regulating Blood Glucose and Reducing Ghrelin Levels.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND It has been reported that overt and mild thyroid dysfunctions are associated with insulin resistance (IR). We performed this retrospective study to evaluate the relationships between thyroid-stimulating hormone (TSH) levels within the reference range and IR. MATERIAL AND METHODS A total of 447 outpatients were enrolled in this study: 298 with type 2 diabetes mellitus and 149 nondiabetic individuals. Based on a cutoff HbA1c value of 7%, diabetic patients were additionally divided into 2 groups: a high-HbA1c group (n=240) and a low-HbA1c group (n=58). The relationships of TSH levels and HOMA-IR were computed using linear regression models. RESULTS TSH levels were positively and linearly associated with HOMA-IR in both the nondiabetic and diabetic groups (r=0.210, p=0.011 and r=0.451, p<0.001), as well as in the high- and low-HbA1c groups (r=0.507, p<0.001 and r=0.259, p=0.048). A better correlation between TSH levels and HOMA-IR was found in the diabetic group and in the high-HbA1c group when compared with the nondiabetic group and the low-HbA1c group, respectively. Linear regression analysis showed that TSH levels were independently associated with HOMA-IR (p=0.034, =0.049 and <0.001 in nondiabetic, low-, and high-HbA1c groups, respectively). CONCLUSIONS Our data suggest that TSH is independently associated with insulin resistance.
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