ArticleInternational journal of molecular sciences2018
Cytotoxicity Evaluation of Turmeric Extract Incorporated Oil-in-Water Nanoemulsion.
Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Design and Optimization of Self-Nanoemulsifying Drug Delivery Systems to Enhance the Anti-Inflammatory Efficacy ofPharmaceutics · 2026Article
- Nanoemulsion-Mediated Suppression of Multidrug-Resistant Klebsiella pneumoniae via Oxygen Consumption Reduction and Biofilm Inhibition.Current microbiology · 2026Article
- Stabilizing Nanoemulsions with Blended Biosurfactants: Role of Sophorolipids and Lecithin in Emulsion Performance.Biotech (Basel (Switzerland)) · 2026Article
- Antiparasitic activity of peppermint and lavender essential oil nano-emulsions against Toxoplasma gondii RH strain in vitro and in vivo.Veterinary research communications · 2026Article
- Unearthing anti-MRSA agents from alpine lichens: discovery and characterization of bioactive compounds inFrontiers in microbiology · 2025Article
- Bioactive Silk Revolution: Harnessing Curcuminoid Dye and Chitosan for Superior Antimicrobial Defence and UV Shielding.Pharmaceutics · 2024Article
- Plant Based Extract Oil-Based Nano emulsions: Impact on Human Melanoma Cell Line.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Nanoemulsions Based on Sunflower and Rosehip Oils: The Impact of Natural and Synthetic Stabilizers on Skin Penetration and an Ex Vivo Wound Healing Model.Pharmaceutics · 2023Article
- The Evaluation of Drug Delivery Nanocarrier Development and Pharmacological Briefing for Metabolic-Associated Fatty Liver Disease (MAFLD): An Update.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Ultrasonic Nanoemulsification ofInternational journal of nanomedicine · 2020Article
- Bioactivity of Curcumin on the Cytochrome P450 Enzymes of the Steroidogenic Pathway.International journal of molecular sciences · 2019Article
- Anticancer and antibacterial effects of a clove bud essential oil-based nanoscale emulsion system.International journal of nanomedicine · 2019Article
- Nano/Micro-Assisted Regenerative Medicine.International journal of molecular sciences · 2018Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To overcome the drawbacks of conventional drug delivery system, nanoemulsion have been developed as an advanced form for improving the delivery of active ingredients. However, safety evaluation is crucial during the development stage before the commercialization. Therefore, the aim of this study was to evaluate the cytotoxicity of two types of newly developed nanoemulsions. Turmeric extract-loaded nanoemulsion powder-10.6 (TE-NEP-10.6, high content of artificial surfactant Tween 80), which forms the optimal nanoemulsion, and the TE-NEP-8.6 made by increasing the content of natural emulsifier (lecithin) to reduce the potential toxicity of nanoemulsion were cultured with various cells (NIH3T3, H9C2, HepG2, hCPC, and hEPC) and the changes of each cell were observed followed by nanoemulsion treatment. As a result, the two nanoemulsions (TE-NEP-10.6 and TE-NEP-8.6) did not show significant difference in cell viability. In the case of cell line (NIH3T3, H9C2, and HepG2), toxicity was not observed at an experimental concentration of less than 1 mg/mL, however, the cell survival rate decreased in a concentration dependent manner in the case of primary cultured cells. These results from our study can be used as a basic data to confirm the cell type dependent toxicity of nanoemulsion.
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