ArticleMolecules (Basel, Switzerland)2018
Honokiol Improves Liver Steatosis in Ovariectomized Mice.
Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Protective effect of phytoestrogens on nonalcoholic fatty liver disease in postmenopausal women.Frontiers in pharmacology · 2023Review
- Honokiol attenuates lipotoxicity in hepatocytes via activating SIRT3-AMPK mediated lipophagy.Chinese medicine · 2021Article
- Protective Effects ofBioMed research international · 2021Article
- Exposure to High-Fat Style Diet Induced Renal and Liver Structural Changes, Lipid Accumulation and Inflammation in Intact and Ovariectomized Female Rats.Journal of inflammation research · 2021Article
- Quercitrin Ameliorates Hyperlipidemia and Hepatic Steatosis in Ovariectomized Mice.Life (Basel, Switzerland) · 2020Article
- NAFLD and NASH in Postmenopausal Women: Implications for Diagnosis and Treatment.Endocrinology · 2020Review
- Article
- Blackcurrant (Nutrients · 2020Article
- Preventive Effects ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Article
- Review
- Metformin ameliorates body mass gain and early metabolic changes in ovariectomized rats.Endocrine connections · 2019Article
- Protective Effects of 2,3,5,4'-Tetrahydroxystilbene-2-International journal of molecular sciences · 2018Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease, and is associated with the development of metabolic syndrome. Postmenopausal women with estrogen deficiency are at a higher risk of progression to NAFLD. Estrogen has a protective effect against the progression of the disease. Currently, there are no safe and effective treatments for these liver diseases in postmenopausal women. Honokiol (Ho), a bioactive natural product derived from Magnolia spp, has anti-inflammatory, anti-angiogenic, and anti-oxidative properties. In our study, we investigated the beneficial effects of Ho on NAFLD in ovariectomized (OVX) mice. We divided the mice into four groups, as follows: SHAM, OVX, OVX+β-estradiol (0.4 mg/kg of bodyweight), and OVX+Ho (50 mg/kg of diet). Mice were fed diets with/without Ho for 12 weeks. The bodyweight, epidermal fat, and weights of liver tissue were lower in the OVX group than in the other groups. Ho improved hepatic steatosis and reduced proinflammatory cytokine levels. Moreover, Ho markedly downregulated plasma lipid levels. Our results indicate that Ho ameliorated OVX-induced fatty liver and inflammation, as well as associated lipid metabolism. These findings suggest that Ho may be hepatoprotective against NAFLD in postmenopausal women.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.