ArticleOtology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology2018
Long-term Administration of Salicylate-induced Changes in BDNF Expression and CREB Phosphorylation in the Auditory Cortex of Rats.
Article in Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 14 citations in OpenAlex.
- Regional cerebral blood flow correlates with transcriptional and cellular signatures in tinnitus.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Targeted inhibition of the BDNF/AKT/mTOR pathway in the inferior colliculus ameliorates salicylate-induced tinnitus in rats.iScience · 2026Article
- Application of neurodegenerative disease treatment strategies in tinnitus: mechanisms, translation, and prospects.Frontiers in aging neuroscience · 2026Review
- NMDA Receptors: Next therapeutic targets for Tinnitus?Biochemistry and biophysics reports · 2025Review
- Reversing Cochlear Nucleus Maladaptive Plasticity via Customized Extracochlear Stimulation: A New Approach for Tinnitus Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- An electrophysiological early marker of age-related hearing loss in the Wistar rat model.Heliyon · 2024Article
- Transcriptional-profile changes in the medial geniculate body after noise-induced tinnitus.Experimental biology and medicine (Maywood, N.J.) · 2024Article
- Protective Effect of Resveratrol in an Experimental Model of Salicylate-Induced Tinnitus.International journal of molecular sciences · 2022Article
- Neuroprotective Effect of Valproic Acid on Salicylate-Induced Tinnitus.International journal of molecular sciences · 2021Article
- Glucosamine Enhancement of BDNF Expression and Animal Cognitive Function.Molecules (Basel, Switzerland) · 2020Article
- Chronic tinnitus and BDNF/GDNF CpG promoter methylations: a case-control study.Molecular biology reports · 2019Article
- Changes in GABA and glutamate receptors on auditory cortical excitatory neurons in a rat model of salicylate-induced tinnitus.American journal of translational research · 2018Article
- Analysis of Studies in Tinnitus-Related Gene Research.Noise & healthReview
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10 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
hypothesisWe investigated whether salicylate induces tinnitus through alteration of the expression levels of brain-derived neurotrophic factor (BDNF), proBDNF, tyrosine kinase receptor B (TrkB), cAMP-responsive element-binding protein (CREB), and phosphorylated CREB (p-CREB) in the auditory cortex (AC).
backgroundSalicylate medication is frequently used for long-term treatment in clinical settings, but it may cause reversible tinnitus. Salicylate-induced tinnitus is associated with changes related to central auditory neuroplasticity. Our previous studies revealed enhanced neural activity and ultrastructural synaptic changes in the central auditory system after long-term salicylate administration. However, the underlying mechanisms remained unclear.
methodsSalicylate-induced tinnitus-like behavior in rats was confirmed using gap prepulse inhibition of acoustic startle and prepulse inhibition testing, followed by comparison of the expression levels of BDNF, proBDNF, TrkB, CREB, and p-CREB. Synaptic ultrastructure was observed under a transmission electron microscope.
resultsBDNF and p-CREB were upregulated along with ultrastructural changes at the synapses in the AC of rats treated chronically with salicylate (p < 0.05, compared with control group). These changes returned to normal after 14 days of recovery (p > 0.05).
conclusionLong-term administration of salicylate increased BDNF expression and CREB activation, upregulated synaptic efficacy, and changed synaptic ultrastructure in the AC. There may be a relationship between these factors and the mechanism of tinnitus.
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