ArticleOtology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology2018
Preservation of Cells of the Organ of Corti and Innervating Dendritic Processes Following Cochlear Implantation in the Human: An Immunohistochemical Study.
Article in Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Electrode impedance in cochlear implantation: determinants, dynamics, and clinical implications.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Review
- Long-term in vivo pharmacokinetics of dexamethasone-loaded cochlear implant electrode carrier dummies with optimized release profiles.Scientific reports · 2026Article
- Anatomical Integrity of the Human Cochlea Estimated with Optical Coherence Tomography for Future Clinical Application.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Anatomical integrity of the human cochlea estimated with optical coherence tomography for future clinical application.bioRxiv : the preprint server for biology · 2025Article
- Supporting cell involvement in cochlear damage and repair: Novel insights from a quantitative analysis of cyclodextrin-induced ototoxicity in mice.Hearing research · 2025Article
- Effects of Microstructured and Anti-Inflammatory-Coated Cochlear Implant Electrodes on Fibrous Tissue Growth and Neuronal Survival.Journal of functional biomaterials · 2025Article
- Using x-ray micro computed tomography to quantify intracochlear fibrosis after cochlear implantation in a Guinea pig model.Heliyon · 2023Article
- Supporting-cell vs. hair-cell survival in the human cochlea: Implications for regenerative therapies.Hearing research · 2023Article
- Supporting-cell vs. hair-cell survival in the human cochlea: Implications for regenerative therapies.bioRxiv : the preprint server for biology · 2023Article
- Cochlear Health and Cochlear-implant Function.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- Factors influencing the relationship between cochlear health measures and speech recognition in cochlear implant users.Frontiers in integrative neuroscience · 2023Article
- Vestibular function after simultaneous bilateral cochlear implantation in adults.Frontiers in neurology · 2023Article
- Cochlear implants: Causes, effects and mitigation strategies for the foreign body response and inflammation.Hearing research · 2022Review
- Evaluation of the Efficacy of Dexamethasone-Eluting Electrode Array on the Post-Implant Cochlear Fibrotic Reaction by Three-Dimensional Immunofluorescence Analysis in Mongolian Gerbil Cochlea.Journal of clinical medicine · 2021Article
- Metabolic reprogramming of inner ear cell line HEI-OC1 after dexamethasone application.Metabolomics : Official journal of the Metabolomic Society · 2021Article
- Spiral Ganglions and Speech Perception in the Elderly. Which Turn of the Cochlea is the More Relevant? A Preliminary Study on Human Temporal Bones.The journal of international advanced otology · 2020Article
- The Distribution and Prevalence of Macrophages in the Cochlea Following Cochlear Implantation in the Human: An Immunohistochemical Study Using Anti-Iba1 Antibody.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2020Article
- Contemporary techniques in human otopathology and promise for the future.Laryngoscope investigative otolaryngology · 2020Review
- Immune Response After Cochlear Implantation.Frontiers in neurology · 2020Article
- Long-TermFrontiers in neurology · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
hypothesisThis study evaluates the degree of preservation of hair cells, supporting cells, and innervating dendritic processes after cochlear implantation in the human using immunohistochemical methods.
backgroundSurgical insertion of a cochlear implant electrode induces various pathologic changes within the cochlea including insertional trauma, foreign body response, inflammation, fibrosis, and neo-osteogenesis. These changes may result in loss of residual acoustic hearing, adversely affecting the use of hybrid implants, and may result in loss of putative precursor cells, limiting the success of future regenerative protocols.
methodsTwenty-eight celloidin-embedded temporal bones from 14 patients with bilateral severe to profound sensorineural hearing loss and unilateral cochlear implants were studied. Two sections including the modiolus or basal turn from each temporal bone were stained using antineurofilament, antimyosin-VIIa, and antitubulin antibodies in both the implanted and unimplanted ears.
resultsInner and outer hair cells: Immunoreactivity was reduced throughout the implanted cochlea and in the unimplanted cochlea with the exception of the apical turn.Dendritic processes in the osseous spiral lamina: Immunoreactivity was significantly less along the electrode of the implanted cochlea than in the other segments.Inner and outer pillars, inner and outer spiral bundles, and Deiters' cells: Immunoreactivity was similar in the implanted and unimplanted cochleae.
conclusionInsertion of a cochlear implant electrode may significantly affect the inner and outer hair cells both along and apical to the electrode, and dendritic processes in the osseous spiral lamina along the electrode. There was less effect on pillar cells, Deiters' cells, and spiral bundles.
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