ArticlePhysiological genomics2018
Evidence of genetic predisposition for metabolically healthy obesity and metabolically obese normal weight.
Article in Physiological genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Lactoferrin Deficiency During Lactation Causes Adult Obesity-Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Genetic and molecular signatures highlight diverse pathways linking obesity to type 2 diabetes.Nature communications · 2026Article
- Genomics link obesity and type 2 diabetes to Alzheimer's disease to unveil novel biological insights.medRxiv : the preprint server for health sciences · 2026Article
- iPLA2β-null mice exposed to natural pathogens exhibit hepatocellular fibrotic injury with male-biased alteration of glycerolipid metabolism.Frontiers in immunology · 2026Article
- Exploring the genetic intersection between obesity-associated genetic variants and insulin sensitivity indices.Scientific reports · 2025Article
- Metabolic state and female fertility in ART cycles: a summary of current advances.Frontiers in cell and developmental biology · 2025Review
- Genetic determinants of obesity in Korean populations: exploring genome-wide associations and polygenic risk scores.Briefings in bioinformatics · 2024Article
- Diagnostic accuracy of anthropometric indices for metabolically healthy obesity in child and adolescent population.Pediatric research · 2023Article
- Precision nutrition for targeting pathophysiology of cardiometabolic phenotypes.Reviews in endocrine & metabolic disorders · 2023Review
- Genetic Background of Metabolically Healthy and Unhealthy Obesity Phenotypes in Hungarian Adult Sample Population.International journal of molecular sciences · 2023Article
- Genetic Effect on Body Mass Index and Cardiovascular Disease Across Generations.Circulation. Genomic and precision medicine · 2023Article
- Diagnostic accuracy of the waist-to-height ratio and other anthropometric indices for metabolically healthy obesity in the working population.Frontiers in nutrition · 2022Article
- The acute vs. chronic effect of exercise on insulin sensitivity: nothing lasts forever.Cardiovascular endocrinology & metabolism · 2021Review
- Cancer Risk in Normal Weight Individuals with Metabolic Obesity: A Narrative Review.Cancer prevention research (Philadelphia, Pa.) · 2021Review
- Obesity, metabolic health and omics: Current status and future directions.World journal of diabetes · 2021Review
- Understanding the genetic architecture of the metabolically unhealthy normal weight and metabolically healthy obese phenotypes in a Korean population.Scientific reports · 2021Article
- Homeostasis Disrupted and Restored-A Fresh Look at the Mechanism and Treatment of Obesity During COVID-19.Frontiers in cardiovascular medicine · 2021Review
- Rescue of Hepatic Phospholipid Remodeling Defectin iPLA2β-Null Mice Attenuates Obese but Not Non-Obese Fatty Liver.Biomolecules · 2020Review
- The triglycerides and glucose index is associated with cardiovascular risk factors in metabolically obese normal-weight subjects.Journal of endocrinological investigation · 2020Article
- Physiological and Lifestyle Traits of Metabolic Dysfunction in the Absence of Obesity.Current diabetes reports · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Obesity has evolved into a global pandemic that constitutes a major threat to public health. The majority of obesity-related health care costs are due to cardiometabolic complications, such as insulin resistance, dyslipidemia, and hypertension, which are risk factors for Type 2 diabetes and cardiovascular disease. However, many obese individuals, often called metabolically healthy obese (MHO), seem to be protected from these cardiometabolic complications. Conversely, there is a group of individuals who suffer from cardiometabolic complications despite being of normal weight; a condition termed metabolically obese normal weight (MONW). Recent large-scale genomic studies have provided evidence that a number of genetic variants show an association with increased adiposity but a favorable cardiometabolic profile, an indicator for the genetic basis of the MHO and MONW phenotypes. Many of these loci are located in or near genes that implicate pathways involved in adipogenesis, fat distribution, insulin signaling, and insulin resistance. It has been suggested that a threshold for subcutaneous adipose tissue expandability may be at play in the manifestation of MHO and MONW, where expiry of adipose tissue storage capacity could lead to ectopic lipid accumulation in non-adipose tissues such as liver, muscle, heart, and pancreatic beta cells. Understanding the genetic aspects of the mechanisms that underpin MHO and MONW is crucial to define appropriate public health action points and to develop effective intervention measures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.