Evidence map›Paper›PMID 29341826›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2018

µ-Opioid receptors inhibit the exercise pressor reflex by closing N-type calcium channels but not by opening GIRK channels in rats.

Juan A Estrada, Marc P Kaufman

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Oxytocin-Modulated Ion Channel Ensemble Controls Depolarization, Integration and Burst Firing in CA2 Pyramidal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  5. Article
  6. Chronic ablation of TRPV1-sensitive skeletal muscle afferents attenuates the muscle metaboreflex.American journal of physiology. Regulatory, integrative and comparative physiology · 2021
    Article
  7. Intrathecal injection of brilliant blue G, a P2X7 antagonist, attenuates the exercise pressor reflex in rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2020
    Article
  8. The magnitude of the exercise pressor reflex is influenced by the active skeletal muscle mass in the decerebrate rat.American journal of physiology. Regulatory, integrative and comparative physiology · 2020
    Article
  9. Stimulation of spinal δ-opioid receptors attenuates the exercise pressor reflex in decerebrate rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2019
    Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Juan A EstradaHeart and Vascular Institute, Penn State College of Medicine , Hershey, Pennsylvania.
Marc P KaufmanHeart and Vascular Institute, Penn State College of Medicine , Hershey, Pennsylvania.
Penn State Milton S. Hershey Medical Center · US

Funding

Project 3: Role Played by ASIC, P2X and EP4 Receptors in the Exercise Pressor Reflex in Health and Simulated PADP01HL134609 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KAUFMAN, MARC PETER · 2017 to 2021
$9.4M
Excitability of Afferents Evoking the Exercise Pressor ReflexR01AR059397 · NIAMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI ELMSLIE, KEITH S, KAUFMAN, MARC PETER · 2010 to 2019
$5.4M
NHLBI NIH HHS P01 HL134609NIAMS NIH HHS R01 AR059397
6 · The paper itself

Abstract

µ-Opioid G protein-coupled receptors (MOR) interact with ion channels to decrease neuronal excitability. In humans, intrathecal administration of the MOR agonist fentanyl inhibits the exercise pressor reflex, an effect that can be attributed to either the opening of inward rectifying potassium channels (GIRK) or the closing of N-type calcium channels. The purpose of this study was to determine if the highly selective MOR agonist [d-Ala

Indexed as

Ion Channel GatingNeural InhibitionPhysical ExertionReflexAnalgesics, OpioidAnimalsCalcium Channel BlockersCalcium Channels, N-TypeCalcium SignalingDecerebrate StateEnkephalin, Ala(2)-MePhe(4)-Gly(5)-G Protein-Coupled Inwardly-Rectifying Potassium ChannelsInjections, SpinalMaleMuscle ContractionMuscle, SkeletalAnalgesics, OpioidCacna1b protein, ratCalcium Channel BlockersCalcium Channels, N-TypeEnkephalin, Ala(2)-MePhe(4)-Gly(5)-G Protein-Coupled Inwardly-Rectifying Potassium ChannelsPotassium Channel BlockersReceptors, Opioid, muarterial pressureautonomic functioncirculatory controlGIRK channelsheart ratesympathetic nervous system

Identifiers

PMID29341826
PMCPMC6008115
OpenAlexW2782794273

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.