Evidence map›Paper›PMID 29341431›Full record

ArticleAmerican journal of medical genetics. Part A2018

Risk of infantile hemangiomas in the offspring of women with autoimmune disease and the pathogenic implications of these lesions.

Chelsey J F Smith, Kenneth L Jones, Diana L Johnson, Gretchen Bandoli, Loan K Robinson, Arthur Kavanaugh, Christina D Chambers

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of medical genetics. Part A, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Chelsey J F SmithDivision of Rheumatology, Allergy, Immunology, University of California San Diego, La Jolla, California.ORCID 0000-0001-5250-2908
Kenneth L JonesDepartment of Pediatrics, University of California San Diego, San Diego, California.
Diana L JohnsonDepartment of Pediatrics, University of California San Diego, San Diego, California.
Gretchen BandoliDepartment of Pediatrics, University of California San Diego, San Diego, California.
Loan K RobinsonDepartment of Pediatrics, University of California San Diego, San Diego, California.
Arthur KavanaughDivision of Rheumatology, Allergy, Immunology, University of California San Diego, La Jolla, California.
Christina D ChambersDepartment of Pediatrics, University of California San Diego, San Diego, California.
University of California San Diego · USLa Jolla Institute for Immunology · US

Funding

Rheumatic Diseases Research Training GrantT32AR064194 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GARY S FIRESTEIN, Monica Guma · 2013 to 2026
$3.8M
UC San Diego Clinical and Translational Research InstituteTL1TR001443 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2019
$3.4M
NCATS NIH HHS TL1 TR001443NIAMS NIH HHS T32 AR064194
6 · The paper itself

Abstract

The purpose of this study was to analyze the risk of maternal autoimmune disease or associated treatments on infantile hemangiomas (IHs), a common benign vascular tumor in infants, and to better understand how maternal chronic inflammation may play a factor in the pathogenesis of these lesions. Eligible women from the United States and Canada who enrolled before 19 weeks' gestation and delivered at least one live born infant were recruited as part of the Organization of Teratology Information Specialists (OTIS) Autoimmune Disease in Pregnancy Project from 2004-2013. A total of 51/969 (5.3%) and 8/240 (3.3%) infants with IH were born to mothers with and without autoimmune disease, respectively (OR 1.61; 95%CI, 0.75-.44). The presence of ulcerative colitis (UC) in the mother was significantly associated with IH in the child (OR 3.46; 95%CI, 1.29-9.26). The five largest IH occurred within the autoimmune disease cohort and to women taking a biologic medication. These results imply that UC may be a risk factor for IH development, and that chronic inflammation may influence the development of these lesions. This potential link between IH and autoimmune disease warrants further investigation.

Indexed as

Maternal ExposurePrenatal Exposure Delayed EffectsAutoimmune DiseasesCanadaFemaleHemangiomaHumansInfantInfant, NewbornOdds RatioPopulation SurveillancePregnancyRisk AssessmentRisk FactorsUnited Statesautoimmunebiologicsbirth defectsinfantile hemangiomapregnancy

Identifiers

PMID29341431
PMCPMC5884062
OpenAlexW2791807367

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.