ArticleHippocampus2018
Cardiorespiratory fitness is associated with enhanced hippocampal functional connectivity in healthy young adults.
Article in Hippocampus, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Trial
- Improving fitness increases dentate gyrus/CA3 volume in the hippocampal head and enhances memory in young adults.Hippocampus · 2020Trial
- Associations of physical fitness with brain structure, pathology and cognition in cognitively normal older adults.npj aging · 2026Article
- Exercise Benefits Dentate Gyrus Function: Bridging from Animal Models to Human High-Resolution Functional MRI of Pattern Separation.Advances in neurobiology · 2025Review
- The effort hypothesis at the heart of the virtuous circle.EXCLI journal · 2025Review
- Comparative electroencephalography analysis: Marathon runners during tapering versus sedentary controls reveals no significant differences.Brain and behavior · 2024Article
- Enhanced memory and hippocampal connectivity in humans 2 days after brief resistance exercise.Brain and behavior · 2024Article
- Cardiorespiratory fitness, hippocampal subfield morphology, and episodic memory in older adults.Frontiers in aging neuroscience · 2024Article
- Hippocampal Resting State Functional Connectivity Associated with Physical Activity in Periadolescent Children.Brain sciences · 2023Article
- Relevance of the anterior cingulate cortex volume and personality in motivated physical activity behaviors.Communications biology · 2023Article
- Cardiorespiratory fitness is associated with hippocampal resting state connectivity in women newly diagnosed with breast cancer.Frontiers in cognition · 2023Article
- Exercise as therapy for neurodevelopmental and cognitive dysfunction in people with a Fontan circulation: A narrative review.Frontiers in pediatrics · 2023Review
- Fitness is positively associated with hippocampal formation subfield volumes in schizophrenia: a multiparametric magnetic resonance imaging study.Translational psychiatry · 2022Article
- Getting Fit to Counteract Cognitive Aging: Evidence and Future Directions.Physiology (Bethesda, Md.) · 2022Review
- α7 nicotinic acetylcholine receptors in the hippocampal circuit: taming complexity.Trends in neurosciences · 2022Review
- Daily-Life Physical Activity of Healthy Young Adults Associates With Function and Structure of the Hippocampus.Frontiers in human neuroscience · 2022Article
- Relations between physical activity and hippocampal functional connectivity: Modulating role of mind wandering.Frontiers in human neuroscience · 2022Article
- High Intensity Acute Aerobic Exercise Elicits Alterations in Circulating and Skeletal Muscle Tissue Expression of Neuroprotective Exerkines.Brain plasticity (Amsterdam, Netherlands) · 2022Article
- Evidence for exercise-related plasticity in functional and structural neural network connectivity.Neuroscience and biobehavioral reviews · 2021Review
- Aerobic exercise, cardiorespiratory fitness, and the human hippocampus.Hippocampus · 2021Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Consistent associations have been found between higher cardiorespiratory fitness (CRF) and indices of enhanced brain health and function, including behavioral measures of cognition as well as neuroimaging indicators such as regional brain volume. Several studies have reported that higher CRF levels are associated with a larger hippocampus, yet associations between volume and memory or functional connectivity metrics remain poorly understood. Using a multi-modal framework, we hierarchically examine the association between CRF and hippocampal volume and resting state functional connectivity (rsFC) in younger adults, as well as their relationship between with memory function. We conducted theoretically-driven analyses with seeds in the anterior and posterior hippocampus, as well as control seeds in the caudate nucleus. We tested whether (1) hippocampal connectivity with prefrontal cortical regions was associated with CRF in an adult sample much younger than traditionally tested, (2) associations between CRF and rsFC remain significant after adjusting for volume, and (3) volume and rsFC are related to memory. We found that higher CRF levels were associated with larger anterior hippocampal volume and more positive rsFC of the anterior hippocampus to several regions including the prefrontal cortex. rsFC also accounted for significant variance in CRF, above and beyond volume. CRF can thus be independently linked to increased anterior hippocampal volume, as well as stronger hippocampal rsFC in a population much younger than those typically tested, suggesitng it is critical to maintainig multiple aspects of brain health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.