Evidence map›Paper›PMID 29341222›Full record

ReviewJournal of labelled compounds & radiopharmaceuticals2018

Brooke N McKnight, Nerissa T Viola-Villegas

Abstract readReview
In one paragraph

Review in Journal of labelled compounds & radiopharmaceuticals, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Development of novel GPC2-directed radiotheranostics and CAR T cell therapy for neuroblastoma.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. PET Imaging of CD38 and IND enabling studies of [Molecular imaging and biology · 2026
    Article
  7. Review
  8. A scoping review on potential of novel developments in fever of unknown origin and inflammation of unknown origin: long-axial-field-of-view positron emission tomography/computed tomography and novel radiotracers.The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... · 2025
    Article
  9. European journal of nuclear medicine and molecular imaging · 2024
    Article
  10. Antibody-drug conjugates in gastric cancer: from molecular landscape to clinical strategies.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2024
    Review
  11. Review
  12. Advances and challenges in immunoPET methodology.Frontiers in nuclear medicine · 2024
    Review
  13. Review
  14. Review
  15. Article
  16. Scientific reports · 2022
    Article
  17. Article
  18. Heptadentate chelates forInorganic chemistry frontiers · 2022
    Article
  19. Review
  20. A proof-of-concept study on the use of a fluorescein-basedEJNMMI radiopharmacy and chemistry · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Brooke N McKnightCancer Biology, Wayne State University School of Medicine, Detroit, Michigan, USA.ORCID 0000-0002-9238-419X
Nerissa T Viola-VillegasDepartment of Oncology, Karmanos Cancer Institute, Detroit, Michigan, USA.ORCID 0000-0003-4253-5639

Funding

TRAINING PROGRAM IN THE BIOLOGY OF CANCERT32CA009531 · NCI · WAYNE STATE UNIVERSITY · PI Larry H Matherly · 1985 to 2026
$5.3M
Delineating tumors with resistance to tyrosine kinase therapy via PET imagingR00CA181492 · NCI · WAYNE STATE UNIVERSITY · PI VIOLA, NERISSA THERESE · 2015 to 2017
$662k
NCI NIH HHS R00 CA181492NCI NIH HHS T32 CA009531
6 · The paper itself

Abstract

Therapeutic monoclonal antibodies have been used in cancer treatment for 30 years, with around 24 mAb and mAb:drug conjugates approved by the FDA to date. Despite their specificity, efficacy has remained limited, which, in part, derails nascent initiatives towards precision medicine. An image-guided approach to reinforce treatment decisions using immune positron emission tomography (immunoPET) companion diagnostic is warranted. This review provides a general overview of current translational research using Zr-89 immunoPET and opportunities for utilizing and harnessing this tool to its full potential. Patient case studies are cited to illustrate immunoPET probes as tools for profiling molecular signatures. Discussions on its utility in reinforcing clinical decisions as it relates to histopathological tumor assessment and standard diagnostic methods, and its potential as predictive biomarkers, are presented. We finally conclude with an overview of practical considerations to its utility in the clinic.

Indexed as

Drug DevelopmentRadioisotopesZirconiumAnimalsHumansPositron-Emission TomographyTissue DistributionRadioisotopesZirconiumZirconium-89antibodyclinical trialscompanion diagnosticsimagingImmunoPET

Identifiers

PMID29341222
PMCPMC6050145

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.