ArticleJournal of the American Geriatrics Society2018
Personality Changes During the Transition from Cognitive Health to Mild Cognitive Impairment.
Article in Journal of the American Geriatrics Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Meta-analyses of personality change from the preclinical to the clinical stages of dementia.Ageing research reviews · 2025Pooled it
- Effects of music participation for mild cognitive impairment and dementia: A systematic review and meta-analysis.Journal of the American Geriatrics Society · 2021Pooled it
- Abnormal FDG-PET Patterns and Amyloid Positivity Predict Personality Changes in Cognitively Preserved Individuals.Brain sciences · 2026Article
- Emotion Dynamics in Young and Cognitively Diverse Older Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- A Systematic Review on Subjective Cognitive Complaints: Main Neurocognitive Domains, Myriad Assessment Tools, and New Approaches for Early Detection.Geriatrics (Basel, Switzerland) · 2025Review
- Assessing the Acceptability and Potential Emotional Well-being Outcomes of a Digital, Intergenerational Music Program for Older Adults Living With Dementia.Journal of intergenerational relationships · 2025Article
- A Qualitative Pilot Study of Adolescents' Characteristics and Experiences Delivering a Digital, Intergenerational Music Program to Older Adults with Alzheimer's and Dementia.Journal of intergenerational relationships · 2025Article
- Risk-Taking Behavior Differs Between Older Adults with and without Mild Cognitive Impairment.Journal of Alzheimer's disease : JAD · 2024Article
- Feasibility of adolescent musicians in delivering Project Unmute, a virtual, intergenerational active music-based intervention for older adults with Alzheimer's disease and dementia.International journal of music, health, and wellbeing · 2024Article
- Changes in Personality Before and During Cognitive Impairment.Journal of the American Medical Directors Association · 2023Observational
- Personality traits and disorders in Alzheimer's disease.Brain and behavior · 2023Article
- Effects of Longitudinal Changes in Neuroticism and Stress on Cognitive Decline.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023Observational
- Comparing the Experiences of Participants With Mild Cognitive Impairment and Mild Dementia During an Oral Health Intervention.Innovation in aging · 2023Article
- Association of 1-year change in neuroticism and 3-year change in cognitive performance among older depressed adults.International psychogeriatrics · 2022Observational
- Suicide risk in first year after dementia diagnosis in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Galectin-3 Involvement in Cognitive Processes for New Therapeutic Considerations.Frontiers in cellular neuroscience · 2022Review
- Facets of Personality and Risk of Cognitive Impairment: Longitudinal Findings in a Rural Community from Sardinia.Journal of Alzheimer's disease : JAD · 2022Article
- Mild Behavioral Impairment and Subjective Cognitive Decline Predict Cognitive and Functional Decline.Journal of Alzheimer's disease : JAD · 2021Article
- Article
- Change in weight and personality in middle-aged and older adults.Psychology & health · 2020Article
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND/
objectivesBehavioral problems in individuals with Alzheimer's disease (AD) impose major management challenges. Current prevention strategies are anchored to cognitive outcomes, but behavioral outcomes may provide another, clinically relevant opportunity for preemptive therapy. We sought to determine whether personality changes that predispose to behavioral disorders arise during the transition from preclinical AD to mild cognitive impairment (MCI).
designLongitudinal observational cohort study.
settingAcademic medical center.
participantsMembers of an apolipoprotein E (APOE) ɛ4 genetically enriched cohort of Maricopa County residents who were neuropsychiatrically healthy at entry (N = 277). Over a mean interval of 7 years, 25 who developed MCI and had the Neuroticism, Extraversion, and Openness Personality Inventory-Revised (NEO-PI-R) before and during the MCI transition epoch were compared with 252 nontransitioners also with serial NEO-PI-R administrations.
interventionLongitudinal administration of the NEO-PI-R and neuropsychological test battery. MEASUREMENTS: Change in NEO-PI-R factor scores (neuroticism, extraversion, openness, agreeableness, conscientiousness) from entry to the epoch of MCI diagnosis or an equivalent follow-up duration in nontransitioners.
resultsNEO-PI-R neuroticism T-scores increased significantly more in MCI transitioners than in nontransitioners (mean 2.9, 95% confidence interval (CI) = 0.9-4.9 vs 0, 95% CI = -0.7-0.7, P = .02), and openness decreased more in MCI transitioners than in nontransitioners (-4.8, 95% CI = -7.3 to -2.4 vs -1.0, 95% CI = -1.6 to -0.4, P < .001). Concurrent subclinical but statistically significant changes in behavioral scores worsened more in MCI transitioners than nontransitioners for measures of depression, somatization, irritability, anxiety, and aggressive attitude.
conclusionPersonality and subclinical behavioral changes begin during the transition from preclinical AD to incident MCI and qualitatively resemble the clinically manifest behavioral disorders that subsequently arise in individuals with frank dementia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.