ArticleMycopathologia2018
Resistance Mechanism in a Terbinafine-Resistant Strain of Microsporum canis.
Article in Mycopathologia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 48 citations in OpenAlex.
- A New Medium that Promotes In Vitro Mass Sporulation of Microsporum canis.Mycopathologia · 2026Article
- Sensitivity of Dermatophytes to Terbinafine: World Experience and Recent Findings from Kazakhstan.Antibiotics (Basel, Switzerland) · 2026Article
- Transcriptome analysis of multi-azole-resistant Microsporum canis isolated from a case of feline dermatophytosis.The Journal of veterinary medical science · 2026Article
- Preparation and Optimization of Voriconazole Gel 0.25% for Topical Delivery in Terbinafine Resistance Dermatophytosis: In Vitro and Pilot Animal Study.Dermatology research and practice · 2026Article
- Terbinafine Resistance inAntibiotics (Basel, Switzerland) · 2025Review
- Establishment and application of multiplex PCR method for detection ofFrontiers in veterinary science · 2025Article
- Antifungal Resistance, Susceptibility Testing and Treatment of Recalcitrant Dermatophytosis Caused by Trichophyton indotineae: A North American Perspective on Management.American journal of clinical dermatology · 2023Review
- Antibacterial and Antimycotic Activity ofPharmaceuticals (Basel, Switzerland) · 2023Review
- Molecular mechanisms of acquired antifungal drug resistance in principal fungal pathogens and EUCAST guidance for their laboratory detection and clinical implications.The Journal of antimicrobial chemotherapy · 2022Review
- Experimental Evolution of Multidrug Resistance inJournal of fungi (Basel, Switzerland) · 2022Article
- Antifungal Resistance in Dermatophytes: Genetic Considerations, Clinical Presentations and Alternative Therapies.Journal of fungi (Basel, Switzerland) · 2021Review
- Antifungal Susceptibility and Mutations in the Squalene Epoxidase Gene in Dermatophytes of the Trichophyton mentagrophytes Species Complex.Antimicrobial agents and chemotherapy · 2021Article
- Belgian National Survey on Tinea Capitis: Epidemiological Considerations and Highlight of Terbinafine-ResistantJournal of fungi (Basel, Switzerland) · 2020Article
- Synergistic Effects of Efflux Pump Modulators on the Azole Antifungal Susceptibility of Microsporum canis.Mycopathologia · 2020Article
- Dermatophyte Resistance to Antifungal Drugs: Mechanisms and Prospectus.Frontiers in microbiology · 2018Review
- The unprecedented epidemic-like scenario of dermatophytosis in India: III. Antifungal resistance and treatment options.Indian journal of dermatology, venereology and leprologyReview
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To clarify the terbinafine (TRF) resistance mechanism in a TRF-resistant strain of Microsporum canis, the expression of the pleiotropic drug resistance (PDR1), multidrug resistance (MDR1), MDR2 and MDR4 genes were investigated by real-time quantitative PCR (RT-qPCR) analysis, given the known interaction of the corresponding proteins with antifungals and with the efflux blocker FK506. The expression of the PDR1, MDR1, MDR2 and MDR4 genes was 2-4 times higher in the TRF-resistant strain grown in the presence of 0.14 µg/mL of TRF than in TRF-susceptible strains cultured in the absence of TRF. The TRF-resistant strain exhibited MICs of > 32 µg/mL for TRF alone; this resistance was attenuated to an MIC of 8 µg/mL in the presence of FK506, indicating that the TRF inhibitory concentration index value was < 0.75. The additive effect of the efflux blocker FK506 on TRF resistance was detected in the TRF-resistant strain. These results indicated that the TRF resistance in this strain reflects overexpression of genes encoding ABC transporter proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.