ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2018
Analysis of fecal microbiota in patients with functional constipation undergoing treatment with synbiotics.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 39 citations in OpenAlex.
- Impact of Probiotic Formula (Lacto-5X) on Constipation: Improvements in Gastrointestinal Symptoms, Gut Microbiome, and Metabolites.Journal of microbiology and biotechnology · 2025Trial
- Regulatory effects of Lactobacillus plantarum HY7714 on skin health by improving intestinal condition.PloS one · 2020Trial
- Clinical Guidance and Practical Recommendations for Probiotic Use in Patients With Irritable Bowel Syndrome, Functional Constipation, andJournal of neurogastroenterology and motility · 2026Review
- Clinical guidance and practical recommendations for probiotic use in patients with irritable bowel syndrome, functional constipation, and Clostridioides difficile infection considering sex-based differences: a Korean translation.Ewha medical journal · 2026Article
- Influences of transcutaneous neuromodulation on fecal microbiota and short chain fatty acids in patients with functional constipation.BMC gastroenterology · 2026Article
- Ruminococcus bromii alleviates constipation by pullulanase-driven resistant starch degradation and microbiota modulation.NPJ biofilms and microbiomes · 2025Article
- Gut-brain axis mediated by intestinal content microbiota was associated with Zhishi Daozhi decoction on constipation.Frontiers in cellular and infection microbiology · 2025Article
- Shaoyao Gancao decoction alleviates functional constipation by inhibitingFrontiers in cellular and infection microbiology · 2025Article
- Microbiota treatment of functional constipation: Current status and future prospects.World journal of hepatology · 2024Review
- Mechanism of Mulberry Leaves and Black Sesame in Alleviating Slow Transit Constipation Revealed by Multi-Omics Analysis.Molecules (Basel, Switzerland) · 2024Article
- Hemp seeds attenuate loperamide-induced constipation in mice.Frontiers in microbiology · 2024Article
- Article
- The Anti-Constipation Effects of Raffino-Oligosaccharide on Gut Function in Mice Using Neurotransmitter Analyses, 16S rRNA Sequencing and Targeted Screening.Molecules (Basel, Switzerland) · 2022Article
- Efficacy ofFrontiers in nutrition · 2022Article
- Effects of Maren Pills on the Intestinal Microflora and Short-Chain Fatty Acid Profile in Drug-Induced Slow Transit Constipation Model Rats.Frontiers in pharmacology · 2022Article
- Current Applications of Fecal Microbiota Transplantation in Functional Constipation.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Changes to the Gut Microbiome in Young Children Showing Early Behavioral Signs of Autism.Frontiers in microbiology · 2022Article
- Dysbiosis in the Gut Microbiome in Streptozotocin-Induced Diabetes Rats and Follow-Up During Retinal Changes.Investigative ophthalmology & visual science · 2021Article
- Gut Metagenome as a Potential Diagnostic and Predictive Biomarker in Slow Transit Constipation.Frontiers in medicine · 2021Article
- Microbial Profiles of Patients With Antipsychotic-Related Constipation Treated With Electroacupuncture.Frontiers in medicine · 2021Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
This study was performed to identify changes to microbial composition after treatment with synbiotics in patients with functional constipation and to define the key microbiota in the pathogenesis of functional constipation. Fecal samples from 53 patients diagnosed with chronic functional constipation according to the Rome III criteria were analyzed using 16S rRNA sequencing. After treatment with synbiotics for 1 month, fecal samples were collected from 36 patients; after a total of 3 months, fecal samples were collected from 15 patients. The outcomes were compared with the intestinal microbiota profiles of 53 healthy community volunteers. The microbiota in the constipation group differed from that in the treatment group and healthy group. After synbiotic treatment for 1 and 3 months, the abundance of Escherichia/Shigella decreased, whereas that of Prevotella_9 and Lactococcus increased. Comparison of the microbiota among the three groups showed that Prevotella_9 was the characteristic bacteria that decreased in the constipation group and increased in the treatment group. Synbiotic treatment can improve the microbiota in patients with constipation. Identification of the key bacterial genus is important to reveal the mechanism and provide a reliable theoretical basis of synbiotic treatment. It will also promote relevant research of microbiota treatment and individualized treatments.
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Registered trials
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