Trial reportSurgical endoscopy2018
Comparison between submucosal tunneling endoscopic resection and video-assisted thoracoscopic enucleation for esophageal submucosal tumors originating from the muscularis propria layer: a randomized controlled trial.
Trial report in Surgical endoscopy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Submucosal Tunneling Endoscopic Resection Versus Endoscopic Submucosal Dissection for Esophageal Submucosal Tumors: A Meta-Analysis.Digestive diseases and sciences · 2026Pooled it
- Efficacy and safety of esophageal submucosal tumors treated with internal traction method-assisted submucosal tunneling endoscopic resection: a single-center, single-blind, randomized controlled study.Surgical endoscopy · 2023Trial
- Feasibility and Safety of Submucosal Tunneling Endoscopic Resection in One Tunnel for Multiple Esophageal Submucosal Tumors Originating from the Muscularis Propria Layer.Digestive diseases and sciences · 2026Article
- Endoscopic resection in treatment of intramural esophageal cysts: Retrospective analysis of 67 cases.Endoscopy international open · 2026Article
- Feasibility and safety of endoscopic resection for cardial submucosal tumors more than 30 mm in diameter.Surgical endoscopy · 2025Article
- Endoscopic resection: A novel approach for treating oesophageal gastrointestinal stromal tumours.World journal of gastrointestinal endoscopy · 2025Article
- Endoscopic treatment outcome of oesophageal gastrointestinal stromal tumours.World journal of gastroenterology · 2025Article
- The efficacy and safety of submucosal tunneling endoscopic resection in treating large esophageal subepithelial lesions.Surgical endoscopy · 2025Article
- Endoscopic Treatment for Gastric Subepithelial Tumor.Journal of gastric cancer · 2024Review
- Submucosal endoscopy: the present and future.Clinical endoscopy · 2023Review
- Clinical outcomes of endoscopic resection for the treatment of gastric gastrointestinal stromal tumors originating from the muscularis propria: a 7-year experience from a large tertiary center in China.Surgical endoscopy · 2022Article
- Lymph node metastasis pattern and significance of left gastric artery lymph node dissection in esophagectomy for esophageal cancers.World journal of surgical oncology · 2021Article
- Complete laparoscopic-transhiatal removal of duplex benign oesophageal tumour: case report and review of literature.BMC gastroenterology · 2021Review
- Feasibility and Safety of Mark-Guided Submucosal Tunneling Endoscopic Resection for Treatment of Esophageal Submucosal Tumors Originating from the Muscularis Propria: A Single-Center Retrospective Study.Canadian journal of gastroenterology & hepatology · 2021Article
- Recent advances in third space or intramural endoscopy.World journal of gastrointestinal endoscopy · 2020Review
- The retrospective comparison between submucosal tunneling endoscopic resection and endoscopic submucosal excavation for managing esophageal submucosal tumors originating from the muscularis propria layer.Surgical endoscopy · 2020Article
- Comparison Between Submucosal Tunneling Endoscopic Resection (STER) and Other Resection Modules for Esophageal Muscularis Propria Tumors: A Retrospective Study.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- 2007-2019: a "Third"-Space Odyssey in the Endoscopic Management of Gastrointestinal Tract Diseases.Current treatment options in gastroenterology · 2019Review
- Consensus on the digestive endoscopic tunnel technique.World journal of gastroenterology · 2019Article
- Endoscopic resection for subepithelial lesions-pure endoscopic full-thickness resection and submucosal tunneling endoscopic resection.Translational gastroenterology and hepatology · 2019Review
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsSurgical resection is considered the first treatment option for submucosal tumors (SMTs) originating from the muscularis propria layer while submucosal tunneling endoscopic resection (STER) is proved to be a safe and effective method for treating SMTs. This study aimed to compare video-assisted thoracoscopic enucleation (VATE) with STER for treating esophageal SMTs.
methodsSixty-six patients with small esophageal SMTs were prospectively randomized from July 2014 to December 2015. After exclusion of 8 patients, 58 subjects scheduled for STER or VATE were enrolled. Clinicopathological, endoscopic, and adverse events (AEs) data were collected and analyzed between STER and VATE.
resultsForty-six males and 12 females with a mean age of 46.1 ± 9.4 years were randomized to the STER (n = 30) and VATE (n = 28) groups, respectively. Demographics and lesion features were similar between the two groups. Median procedure time was shorter in the STER group than the VATE group (44.5 vs. 106.5 min, P < 0.001); cost was lower in the STER group (4499.46 vs. 6137.32 USD, P = 0.010). Median decrease in hemoglobin levels post-procedure was - 1.6 g/L in the STER group and 14.7 g/L after VATE (P = 0.001). Lower postoperative pain scores were found in the STER group compared with the VATE group (2 vs. 4, P < 0.001). No recurrent or residual tumors were found in either group. En bloc resection rates, complete resection rates, hospital times, and post-procedure AEs were similar between two groups. The en bloc resection rates for SMTs < 20.0 mm were 100% in both groups while STER achieved only 71.4% en bloc resection rate for SMTs ≥ 20.0 mm.
conclusionSTER and VATE are comparably effective for esophageal SMTs; however, STER is superior to VATE with shorter operation time and decreased cost, and seems safer than VATE. STER is recommended for SMTs < 20.0 mm while VATE is recommended for SMTs with a transverse diameter > 35.0 mm. Clinical trail registration statement: This study is registered at http://www.chictr.org.cn/showproj.aspx?proj=4814 . The registration identification number is ChiCTR-TRC-14004759. The registration date is April 30, 2014.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.