ArticleArchives of women's mental health2018
Longitudinal trajectories of antidepressant use in pregnancy and the postnatal period.
Article in Archives of women's mental health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prescribing behavior of antidepressants for depressive disorders: A systematic review.Frontiers in psychiatry · 2022Pooled it
- Timing of selective serotonin reuptake inhibitor use and risk for preterm birth and related adverse events: with a consideration of the COVID-19 pandemic period.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2024Article
- Postpartum Psychiatric Outcomes and Sick Leave After Discontinuing SSRI or SNRI in Pregnancy.JAMA network open · 2024Article
- Timing of Antidepressant Discontinuation During Pregnancy and Postpartum Psychiatric Outcomes in Denmark and Norway.JAMA psychiatry · 2023Article
- Associations between antidepressant use patterns during pregnancy and birth outcomes among periconception antidepressant users.Pharmacotherapy · 2023Article
- Psychiatric visits during the postpartum year in women with eating disorders who continue or discontinue antidepressant treatment in pregnancy.The International journal of eating disorders · 2023Article
- Longitudinal Methods for Modeling Exposures in Pharmacoepidemiologic Studies in Pregnancy.Epidemiologic reviews · 2022Review
- Trajectories of Prescription Opioid Utilization During Pregnancy Among Prepregnancy Chronic Users and Risk of Neonatal Opioid Withdrawal Syndrome.American journal of epidemiology · 2022Article
- Antidepressant Fill and Dose Trajectories in Pregnant Women with Depression and/or Anxiety: A Norwegian Registry Linkage Study.Clinical epidemiology · 2022Article
- Oral Corticosteroids and Risk of Preterm Birth in the California Medicaid Program.The journal of allergy and clinical immunology. In practice · 2021Article
- Patterns of prenatal antidepressant exposure and risk of preeclampsia and postpartum haemorrhage.Paediatric and perinatal epidemiology · 2020Article
- Prenatal Antidepressant Use and Risk of Adverse Neonatal Outcomes.Pediatrics · 2020Article
- Oral corticosteroid use during pregnancy and risk of preterm birth.Rheumatology (Oxford, England) · 2020Article
- Allopregnanolone in postpartum depression: Role in pathophysiology and treatment.Neurobiology of stress · 2020Review
- Safe Expectations: Current State and Future Directions for Medication Safety in Pregnancy Research.Clinical therapeutics · 2019Article
- Association of Antidepressant Continuation in Pregnancy and Infant Birth Weight.Journal of clinical psychopharmacologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Studies of antidepressant safety in pregnancy typically do not address complex patterns of use throughout pregnancy. We performed longitudinal trajectory modeling to describe patterns of antidepressant use in the first 32 weeks of pregnancy, and test whether these trajectories are associated with a reduction in birth weight or gestational age at delivery. Our study included 166 pregnant women with deliveries between 2011 and 2015 who were prescribed an antidepressant between 91 days prior to last menstrual period and 32 weeks of gestation. From electronic medical records, we estimated average daily dose and cumulative dose per week for the first 32 weeks of gestation and for the first 13 weeks postnatal. We clustered women with similar utilization patterns using k-means longitudinal modeling and assessed the associations between trajectory group and birth weight and gestational age at delivery. We identified four cumulative dose trajectory groups and three average daily dose trajectory groups in each period. Relative to the lowest trajectory group, the highest trajectory group during pregnancy was associated with reduced birth weight in multivariable analysis (average daily highest trajectory vs. lowest trajectory β - 314.1 g, 95% CI - 613.7, - 15.5) adjusted for depression severity score, maternal age, race, and pregnancy smoking. Trajectory groups were not associated with gestational age at delivery. The highest trajectory group of antidepressant use in pregnancy was associated with a modest reduction in birth weight but not with gestational age at delivery. Longitudinal trajectories allow for a dynamic visualization and quantification of medication use among pregnant women.
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Registered trials
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