Evidence map›Paper›PMID 29340520›Full record

ArticleBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2018

Analysis of serum microRNA expression in male workers with occupational noise-induced hearing loss.

Y H Li, Y Yang, Y T Yan, L W Xu, H Y Ma, Y X Shao, C J Cao, X Wu, M J Qi, Y Y Wu and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Noise-Induced Hearing Loss.Journal of clinical medicine · 2023
    Review
  4. NcRNA: key and potential in hearing loss.Frontiers in neuroscience · 2023
    Review
  5. Single-Nucleotide Polymorphisms inBiochemistry research international · 2020
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Y H LiSchool of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Y YangSchool of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Y T YanSchool of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
L W XuSchool of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
H Y MaSchool of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Y X ShaoHangzhou Hospital for the Prevention and Treatment of Occupational Diseases, Hangzhou, Zhejiang, China.
C J CaoHangzhou Hospital for the Prevention and Treatment of Occupational Diseases, Hangzhou, Zhejiang, China.
X WuSchool of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
M J QiSchool of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Y Y WuSchool of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
R ChenSchool of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Y HongSchool of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
X H TanSchool of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
L YangSchool of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Hangzhou Normal University · CNHangzhou Center for Disease Control and Prevention · CNWuhan Prevention and Treatment Center for Occupational Diseases · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Occupational noise-induced hearing loss (ONIHL) is a prevalent occupational disorder that impairs auditory function in workers exposed to prolonged noise. However, serum microRNA expression in ONIHL subjects has not yet been studied. We aimed to compare the serum microRNA expression profiles in male workers of ONIHL subjects and controls. MicroRNA microarray analysis revealed that four serum microRNAs were differentially expressed between controls (n=3) and ONIHL subjects (n=3). Among these microRNAs, three were upregulated (hsa-miR-3162-5p, hsa-miR-4484, hsa-miR-1229-5p) and one was downregulated (hsa-miR-4652-3p) in the ONIHL group (fold change >1.5 and Pbon value <0.05). Real time quantitative PCR was conducted for validation of the microRNA expression. Significantly increased serum levels of miR-1229-5p were found in ONIHL subjects compared to controls (n=10 for each group; P<0.05). A total of 659 (27.0%) genes were predicted as the target genes of miR-1229-5p. These genes were involved in various pathways, such as mitogen-activated protein kinase (MAPK) signaling pathway. Overexpression of miR-1229-5p dramatically inhibited the luciferase activity of 3' UTR segment of MAPK1 (P<0.01). Compared to the negative control, HEK293T cells expressing miR-1229-5p mimics showed a significant decline in mRNA levels of MAPK1 (P<0.05). This preliminary study indicated that serum miR-1229-5p was significantly elevated in ONIHL subjects. Increased miR-1229-5p may participate in the pathogenesis of ONIHL through repressing MAPK1 signaling.

Indexed as

AdultBiomarkersCase-Control StudiesGene Expression RegulationGene OntologyHearing Loss, Noise-InducedHumansMaleMicroRNAsMiddle AgedMitogen-Activated Protein Kinase 1Occupational DiseasesOccupational ExposureReal-Time Polymerase Chain ReactionBiomarkersMicroRNAsMIRN-3162 microRNA, humanMIRN-4484 microRNA, humanMitogen-Activated Protein Kinase 1

Identifiers

PMID29340520
PMCPMC5769754
OpenAlexW2783943197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.