ArticleJournal of translational internal medicine2017
Effect of MTHFR A1298C and MTRR A66G Genetic Mutations on Homocysteine Levels in the Chinese Population: A Systematic Review and Meta-analysis.
Article in Journal of translational internal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Research Progress on the Effect of Exercise on Homocysteine.Current medicinal chemistry · 2026Review
- Effects of methionine synthase and methionine synthase reductase polymorphisms on hypertension susceptibility.Genes & genomics · 2020Article
- Evaluation of right ventricular volume and systolic function in normal fetuses using intelligent spatiotemporal image correlation.World journal of clinical cases · 2019Article
- Associations of MTRR and TSER polymorphisms related to folate metabolism with susceptibility to metabolic syndrome.Genes & genomics · 2019Article
- Combined central retinal vein and cilioretinal artery occlusion in a 25-year-old woman.Romanian journal of ophthalmologyArticle
Corrections and comments
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Authors and funding
16 authors at 11 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesThe Chinese population typically has inadequate folate intake and no mandatory folic acid fortification. Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) are the two key regulatory enzymes in the folate/homocysteine (Hcy) metabolism. Hcy has been implicated in the pathogenesis of cardiovascular disease. We conducted a meta-analysis to assess whether the MTHFR gene A1298C and the MTRR gene A66G polymorphisms affect Hcy levels in the Chinese population.
methodsThis analysis included 13 studies with Hcy levels reported as one of the study measurements. Summary estimates of weighted mean differences and 95% confidence intervals (CIs) were obtained using random-effect models.
resultsOverall, there were no significant differences in Hcy concentrations between participants with the MTHFR 1298 CC (12 trials,
conclusionsNeither the MTHFR A1298C polymorphism nor the MTRR A66G polymorphism affects Hcy levels in the Chinese population.
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Registered trials
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