ArticleTranslational neuroscience2017
Depression is Associated with CRP SNPs in Patients with Family History.
Article in Translational neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Family history, inflammation, and cerebellum in major depression: a combined VBM and dynamic functional connectivity study.Translational psychiatry · 2025Article
- Single nucleotide polymorphisms in C-reactive protein (CRP) predict response to adjunctive celecoxib treatment of resistant bipolar depression.Brain, behavior, & immunity - health · 2023Article
- C-Reactive Protein as a Biomarker for Major Depressive Disorder?International journal of molecular sciences · 2022Review
- State-of-the-Art: Inflammatory and Metabolic Markers in Mood Disorders.Life (Basel, Switzerland) · 2020Review
- Testosterone imbalance may link depression and increased body weight in premenopausal women.Translational psychiatry · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe pathogenesis of depression is not fully understood, but studies have suggested that higher circulating levels of C reactive protein (CRP) might relate to depression occurrence. However, due to the highly variability of individual patients' conditions, the results to date are inconsistent. Considering Single nucleotide polymorphisms (SNPs) of CRP gene have also been suggested to predict plasma CRP levels. In the present study, we hypothesize that inherited CRP allelic variations may co-vary with depressive symptomatology.
methodsWe recruited patients with a diagnosis of depression, with or without family depression history. We then detected serum CRP levels, as well as genome CRP SNPs from participants of this project.
resultsWe found a significantly higher circulating CRP levels in patients with a positive family history. Furthermore, we also identified certain inherited CRP SNPs (A allele in rs1417938 and C allele in rs1205) which could up-regulate serum CRP levels and thus be associated with depression occurrence.
conclusionOur findings raise new evidence for the relationship between circulating CRP level and depression occurrence.
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