Evidence map›Paper›PMID 29339965›Full record

ArticleNeuro-ophthalmology (Aeolus Press)2017

Bilateral Radiation Optic Neuropathy Following Concurrent Chemotherapy and Radiation in Glioblastoma.

Jigisha P Thakkar, John T Slevin, Charles D Smith, Padmaja Sudhakar, William St Clair, John L Villano

Abstract read
In one paragraph

Article in Neuro-ophthalmology (Aeolus Press), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jigisha P ThakkarDepartment of Neurology, University of Kentucky, Lexington, Kentucky, USA.
John T SlevinDepartment of Neurology, University of Kentucky, Lexington, Kentucky, USA.
Charles D SmithDepartment of Neurology, University of Kentucky, Lexington, Kentucky, USA.
Padmaja SudhakarDepartment of Neurology, University of Kentucky, Lexington, Kentucky, USA.
William St ClairDepartment of Radiation Oncology, University of Kentucky, Lexington, Kentucky, USA.
John L VillanoDepartment of Neurology, University of Kentucky, Lexington, Kentucky, USA.
University of Kentucky · USVeterans Health Administration · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiation optic neuropathy (RON) is an iatrogenic complication that causes severe, irreversible vision loss within months to years following radiation to lesions close to the visual pathway. The authors describe a case of RON in glioblastoma after radio-sensitisation with temozolomide with sequential involvement of both optic nerves. This case provides a timeline for clinical and imaging findings with RON and specifically resolution of nerve enhancement. The authors also highlight the potential of an increase in incidence of RON in glioblastoma with advances in survival seen with greater use of second-line chemotherapy and even re-radiation.

Indexed as

Glioblastomaradiation optic neuropathytemozolomide

Identifiers

PMID29339965
PMCPMC5762177
OpenAlexW2617420117

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.