Evidence map›Paper›PMID 29339948›Full record

ArticleGastroenterology & hepatology2017

Update on Functional Heartburn.

Takahisa Yamasaki, Jessica O'Neil, Ronnie Fass

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Gastroenterology & hepatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 37 citations in OpenAlex.

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  14. Role of esophageal manometry and 24-h pH testing in patients with refractory reflux symptoms.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2020
    Article
  15. Article
  16. Alternative Treatments for Minor GI Ailments.Innovations in pharmacy · 2019
    Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Takahisa YamasakiDr Yamasaki is a research fellow at the Esophageal and Swallowing Center at MetroHealth Medical Center in Cleveland, Ohio and a visiting scholar at Case Western Reserve University in Cleveland, Ohio. Ms O'Neil is a medical student at Case Western Reserve University. Dr Fass is the medical director of the Digestive Health Center, director of the Division of Gastroenterology and Hepatology, and head of the Esophageal and Swallowing Center at MetroHealth Medical Center, as well as a professor of medicine at Case Western Reserve University.
Jessica O'NeilDr Yamasaki is a research fellow at the Esophageal and Swallowing Center at MetroHealth Medical Center in Cleveland, Ohio and a visiting scholar at Case Western Reserve University in Cleveland, Ohio. Ms O'Neil is a medical student at Case Western Reserve University. Dr Fass is the medical director of the Digestive Health Center, director of the Division of Gastroenterology and Hepatology, and head of the Esophageal and Swallowing Center at MetroHealth Medical Center, as well as a professor of medicine at Case Western Reserve University.
Ronnie FassDr Yamasaki is a research fellow at the Esophageal and Swallowing Center at MetroHealth Medical Center in Cleveland, Ohio and a visiting scholar at Case Western Reserve University in Cleveland, Ohio. Ms O'Neil is a medical student at Case Western Reserve University. Dr Fass is the medical director of the Digestive Health Center, director of the Division of Gastroenterology and Hepatology, and head of the Esophageal and Swallowing Center at MetroHealth Medical Center, as well as a professor of medicine at Case Western Reserve University.
MetroHealth Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The definition of functional heartburn has been refined over the years. It is currently described, based upon Rome IV criteria, as typical heartburn symptoms in the presence of normal upper endoscopy findings (including normal biopsies), normal esophageal pH testing, and a negative association between symptoms and reflux events. Functional heartburn is very common, affecting women more than men, and with reflux hypersensitivity makes up the majority of heartburn patients who fail twice-daily proton pump inhibitor therapy. These disorders overlap with other functional gastrointestinal disorders and are often accompanied by psychological comorbidities. Diagnosis is made by using endoscopy with esophageal biopsies, wireless pH capsule, pH-impedance monitoring, and high-resolution esophageal manometry. Additional diagnostic tools that may be of value include magnification endoscopy, chromoendoscopy, narrow-band imaging, autofluorescence imaging, mucosal impedance, impedance baseline values, and histopathology scores. Functional heartburn is primarily treated with neuromodulators. Psychological intervention and complementary and alternative medicine may also play important roles in the treatment of these patients.

Indexed as

esophagusHeartburnpH testingproton pump inhibitorupper endoscopy

Identifiers

PMID29339948
PMCPMC5763558
OpenAlexW2910405957

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.