Evidence map›Paper›PMID 29339804›Full record

ArticleScientific reports2018

EPHB6 and testosterone in concert regulate epinephrine release by adrenal gland chromaffin cells.

Yujia Wang, Wei Shi, Alexandre Blanchette, Junzheng Peng, Shijie Qi, Hongyu Luo, Jonathan Ledoux, Jiangping Wu

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Yujia WangResearch Centre, Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, H2X 0A9, Canada.
Wei ShiResearch Centre, Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, H2X 0A9, Canada.
Alexandre BlanchetteMontreal Heart Institute, Montreal, Quebec, H1T 1C8, Canada.
Junzheng PengResearch Centre, Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, H2X 0A9, Canada.
Shijie QiResearch Centre, Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, H2X 0A9, Canada.
Hongyu LuoResearch Centre, Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, H2X 0A9, Canada. hongyu.luo@umontreal.ca.
Jonathan LedouxMontreal Heart Institute, Montreal, Quebec, H1T 1C8, Canada. jonathan.ledoux@umontreal.ca.ORCID http://orcid.org/0000-0001-8540-7763
Jiangping WuResearch Centre, Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, H2X 0A9, Canada. jianping.wu@umontreal.ca.
Centre Hospitalier de l’Université de Montréal · CAMontreal Heart Institute · CAChildren's Hospital of Zhejiang University · CN

Funding

CIHR MOP 123389CIHR MOP123395CIHR MOP69089CIHR MOP97829
6 · The paper itself

Abstract

Erythropoietin-producing human hepatocellular receptor (EPH) B6 (EPHB6) is a member of the receptor tyrosine kinase family. We previously demonstrated that EPHB6 knockout reduces catecholamine secretion in male but not female mice, and castration reverses this phenotype. We showed here that male EPHB6 knockout adrenal gland chromaffin cells presented reduced acetylcholine-triggered Ca

Indexed as

AcetylcholineAdrenal GlandsAnimalsCalciumCatecholaminesCells, CulturedChromaffin CellsEpinephrineFemaleIon TransportLarge-Conductance Calcium-Activated Potassium ChannelsMaleMiceMice, Inbred C57BLMice, KnockoutReceptor, EphB6AcetylcholineCalciumCatecholaminesEpinephrineLarge-Conductance Calcium-Activated Potassium ChannelsReceptor, EphB6Testosterone

Identifiers

PMID29339804
PMCPMC5770418
OpenAlexW2782679216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.