ArticleAnatolian journal of cardiology2018
Association of Interleukin-1 Gene cluster polymorphisms with coronary slow flow phenomenon.
Article in Anatolian journal of cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- The value of diagnosing coronary slow flow based on epicardial adipose tissue radiomics in chest computed tomography.BMC medical imaging · 2025Article
- Single Nucleotide Polymorphisms in Coronary Microvascular Dysfunction.Journal of the American Heart Association · 2024Review
- Inflammation and endothelial function relevant genetic polymorphisms, carotid atherosclerosis, and vascular events in high-risk stroke population.Frontiers in neurology · 2024Article
- Relationship between quantitative epicardial adipose tissue based on coronary computed tomography angiography and coronary slow flow.BMC cardiovascular disorders · 2023Article
- Endothelial nitric oxide synthase Asp298Glu (894G/T) gene polymorphism as a possible risk factor for the coronary slow flow phenomenon among Iranians.BMC cardiovascular disorders · 2022Article
- Interleukin-1 in Coronary Artery Disease.Current topics in medicinal chemistry · 2022Article
- Article
- Increased plasma lipoprotein-associated phospholipase A2 levels are associated with coronary slow flow.BMC cardiovascular disorders · 2020Article
- Interleukin-1 gene cluster polymorphisms associated with coronary slow flow phenomenon.Anatolian journal of cardiology · 2018Article
- Author`s Reply.Anatolian journal of cardiology · 2018Article
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Abstract
objectiveCoronary slow flow phenomenon (CSFP) is characterized by the decreased rate of contrast progression in epicardial coronary arteries in the absence of significant coronary stenosis. Mounting evidence has showed a significant association between inflammation and CSFP severity. This study aimed to evaluate possible associations between interleukin-1 receptor antagonist (IL-1ra) gene variable number tandem repeat (VNTR), IL-1ß -511 single nucleotide (SNP), and IL-1ß+3954 SNP mutations with CSFP.
methodsForty-eight patients with CSFP and 62 controls with angiographically normal coronary arteries were prospectively enrolled in the study. Genotypes were assessed using the polymerase chain reaction (PCR)-based restriction fragment length polymorphism (PCR-RFLP) technique.
resultsHomozygote genotype for allele 2 of+3954 C>T 2/2 genotype was significantly more frequent in patients with CSFP than in the control group, whereas 1/2 genotype was more frequent in the control group (35.4% versus 14.5% for 2/2 genotype and 25% versus 35.5% for 1/2 genotype in CSFP and control groups, respectively, X
conclusionIL-1ß+3954 SNP mutations are significantly more common in patients with CSFP. It may suggest that the tendency for inflammation may contribute to the presence of this phenomenon.
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