ReviewThe Journal of biological chemistry2018
Mechanisms of redox metabolism and cancer cell survival during extracellular matrix detachment.
Review in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Transcriptomic profiling reveals autophagy-associated programs and prognostic biomarkers in anoikis-resistant pancreatic cancer cells.BMC cancer · 2026Article
- Bioactive Natural Compounds in Triple-Negative Breast Cancer: Molecular Targets and Therapeutic Perspectives.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Metabolic adaptations in cancer progression.Physiological reviews · 2026Review
- Emerging role of bile acids in colorectal liver metastasis: From molecular mechanism to clinical significance (Review).International journal of oncology · 2025Review
- Prognostic significance and therapeutic implications of redox metabolism-related genes in head and neck squamous cell carcinoma.Experimental biology and medicine (Maywood, N.J.) · 2025Article
- FASN contributes to ADM resistance of diffuse large B-cell lymphoma by inhibiting ferroptosis via nf-κB/STAT3/GPX4 axis.Cancer biology & therapy · 2024Article
- Glutathione Dynamics in the Tumor Microenvironment: A Potential Target of Cancer Stem Cells and T Cells.International journal of stem cells · 2024Review
- Multitarget Pharmacology of Sulfur-Nitrogen Heterocycles: Anticancer and Antioxidant Perspectives.Antioxidants (Basel, Switzerland) · 2024Review
- Mitochondrial division inhibitor (mdivi-1) induces extracellular matrix (ECM)-detachment of viable breast cancer cells by a DRP1-independent mechanism.Scientific reports · 2024Article
- Anchorage Dependence and Cancer Metastasis.Journal of Korean medical science · 2024Review
- Regulation of antioxidants in cancer.Molecular cell · 2024Review
- The critical role of glutamine and fatty acids in the metabolic reprogramming ofFrontiers in pharmacology · 2024Article
- The Association Between Mitochondrial tRNAPharmacogenomics and personalized medicine · 2024Article
- Metabolic heterogeneity in cancer.Nature metabolism · 2024Review
- Extracellular matrix detached cancer cells resist oxidative stress by increasing histone demethylase KDM6 activity.Saudi journal of biological sciences · 2024Article
- Involvement of redox signalling in tumour cell dormancy and metastasis.Cancer metastasis reviews · 2023Review
- Iron affects the sphere-forming ability of ovarian cancer cells in non-adherent culture conditions.Frontiers in cell and developmental biology · 2023Article
- Assessment of Metabolic Pathways and Parameters in Extracellular Matrix-Detached Cells.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Acidic ascites inhibits ovarian cancer cell proliferation and correlates with the metabolomic, lipidomic and inflammatory phenotype of human patients.Journal of translational medicine · 2022Article
- Detachment stress mediated bioenergetic switch of malignant melanoma cells into anti-Warburg phenotype.Aging · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nontransformed cells that become detached from the extracellular matrix (ECM) undergo dysregulation of redox homeostasis and cell death. In contrast, cancer cells often acquire the ability to mitigate programmed cell death pathways and recalibrate the redox balance to survive after ECM detachment, facilitating metastatic dissemination. Accordingly, recent studies of the mechanisms by which cancer cells overcome ECM detachment-induced metabolic alterations have focused on mechanisms in redox homeostasis. The insights into these mechanisms may inform the development of therapeutics that manipulate redox homeostasis to eliminate ECM-detached cancer cells. Here, we review how ECM-detached cancer cells balance redox metabolism for survival.
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