ArticleScience signaling2018
Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia.
Article in Science signaling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Updates on the Pathogenesis and Therapeutic Approaches for Hereditary Hemorrhagic Telangiectasia.Current vascular pharmacology · 2025Review
- Hereditary hemorrhagic telangiectasia: from signaling insights to therapeutic advances.The Journal of clinical investigation · 2024Review
- Genetics architecture of spontaneous coronary artery dissection in an Italian cohort.Frontiers in cardiovascular medicine · 2024Article
- Essential role of the amino-terminal region of Drosha for the Microprocessor function.iScience · 2023Article
- Deficiency in hereditary hemorrhagic telangiectasia-associated Endoglin elicits hypoxia-driven heart failure in zebrafish.Disease models & mechanisms · 2023Article
- Neurovascular Interactions in the Development of the Vasculature.Life (Basel, Switzerland) · 2022Review
- DROSHA but not DICER is required for human haematopoietic stem cell function.Clinical & translational immunology · 2022Article
- GNAQ mutations drive port wine birthmark-associated Sturge-Weber syndrome: A review of pathobiology, therapies, and current models.Frontiers in human neuroscience · 2022Review
- Review of treatment and therapeutic targets in brain arteriovenous malformation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Review
- Control of ribosomal protein synthesis by the Microprocessor complex.Science signaling · 2021Article
- Non-Coding RNAs and Hereditary Hemorrhagic Telangiectasia.Journal of clinical medicine · 2020Review
- Differential Expression of Circulating Plasma miRNA-370 and miRNA-10a from Patients with Hereditary Hemorrhagic Telangiectasia.Journal of clinical medicine · 2020Article
- Recent Advances in Basic Research for Brain Arteriovenous Malformation.International journal of molecular sciences · 2019Review
- Deregulation of Drosha in the pathogenesis of hereditary hemorrhagic telangiectasia.Current opinion in hematology · 2019Review
- MicroRNA regulation of vascular function.Vascular biology (Bristol, England) · 2019Review
- SMAD4 Prevents Flow Induced Arteriovenous Malformations by Inhibiting Casein Kinase 2.Circulation · 2018Article
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12 authors.
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Abstract
The transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) family of cytokines critically regulates vascular morphogenesis and homeostasis. Impairment of TGF-β or BMP signaling leads to heritable vascular disorders, including hereditary hemorrhagic telangiectasia (HHT). Drosha, a key enzyme for microRNA (miRNA) biogenesis, also regulates the TGF-β and BMP pathway through interaction with Smads and their joint control of gene expression through miRNAs. We report that mice lacking
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