Evidence map›Paper›PMID 29339522›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Effect of beta-agonists on LAM progression and treatment.

Kang Le, Wendy K Steagall, Mario Stylianou, Gustavo Pacheco-Rodriguez, Thomas N Darling, Martha Vaughan, Joel Moss

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Lymphangioleiomyomatosis and pregnancy: a mini-review.Archives of gynecology and obstetrics · 2024
    Review
  3. Review
  4. Article
  5. Raising the Flag for Mast Cells as a Novel Target in Lymphangioleiomyomatosis.American journal of respiratory and critical care medicine · 2021
    Article
  6. Lymphangioleiomyomatosis: a clinical review.Breathe (Sheffield, England) · 2020
    Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kang LePulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
Wendy K SteagallPulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892; steagalw@nhlbi.nih.gov vaughanm@nih.gov mossj@nhlbi.nih.gov.
Mario StylianouOffice of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
Gustavo Pacheco-RodriguezPulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
Thomas N DarlingDepartment of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814.
Martha VaughanPulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892; steagalw@nhlbi.nih.gov vaughanm@nih.gov mossj@nhlbi.nih.gov.
Joel MossPulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892; steagalw@nhlbi.nih.gov vaughanm@nih.gov mossj@nhlbi.nih.gov.
National Heart Lung and Blood Institute · USNational Institutes of Health · USUniformed Services University of the Health Sciences · US

Funding

Characterization of the Pathogenesis of Lymphangioleiomyomatosis (LAM)ZIAHL002541 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI MOSS, JOEL · 2009 to 2025
$47.7M
6 · The paper itself

Abstract

Lymphangioleiomyomatosis (LAM), a rare disease of women, is associated with cystic lung destruction resulting from the proliferation of abnormal smooth muscle-like LAM cells with mutations in the tuberous sclerosis complex (TSC) genes

Indexed as

Adrenergic beta-AgonistsAdultAgedBronchodilator AgentsCatalytic DomainCell ProliferationCyclic AMPCyclic AMP-Dependent Protein KinasesDisease ProgressionFemaleFibroblastsHumansIsoproterenolLymphangioleiomyomatosisMiddle AgedMultivariate AnalysisAdrenergic beta-AgonistsBronchodilator AgentsCyclic AMPCyclic AMP-Dependent Protein KinasesIsoproterenolMTOR protein, humanSirolimusTOR Serine-Threonine KinasesTSC1 protein, humanTSC2 protein, humanTuberous Sclerosis Complex 1 ProteinTuberous Sclerosis Complex 2 ProteinTumor Suppressor Proteinsbronchodilatorscyclic AMPlymphangioleiomyomatosissirolimustuberous sclerosis complex

Identifiers

PMID29339522
PMCPMC5798385
OpenAlexW2783940258

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.