Evidence map›Paper›PMID 29339520›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Targeted knockout of a chemokine-like gene increases anxiety and fear responses.

Jung-Hwa Choi, Yun-Mi Jeong, Sujin Kim, Boyoung Lee, Krishan Ariyasiri, Hyun-Taek Kim, Seung-Hyun Jung, Kyu-Seok Hwang, Tae-Ik Choi, Chul O Park and 17 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 49 citations in OpenAlex.

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  12. Disease Modeling of Rare Neurological Disorders in Zebrafish.International journal of molecular sciences · 2022
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  19. Review
  20. Zebrafish as an animal model for biomedical research.Experimental & molecular medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 12 institutions in 7 countries.

Jung-Hwa ChoiDepartment of Biology, Chungnam National University, 34134 Daejeon, South Korea.ORCID 0000-0002-0591-9708
Yun-Mi JeongDepartment of Biology, Chungnam National University, 34134 Daejeon, South Korea.
Sujin KimInstitute for Basic Science School, University of Science and Technology, 34113 Daejeon, South Korea.
Boyoung LeeCenter for Cognition and Sociality, Institute for Basic Science, 34141 Daejeon, South Korea.
Krishan AriyasiriDepartment of Biology, Chungnam National University, 34134 Daejeon, South Korea.
Hyun-Taek KimDepartment of Biology, Chungnam National University, 34134 Daejeon, South Korea.
Seung-Hyun JungDepartment of Biology, Chungnam National University, 34134 Daejeon, South Korea.
Kyu-Seok HwangDepartment of Biology, Chungnam National University, 34134 Daejeon, South Korea.
Tae-Ik ChoiDepartment of Biology, Chungnam National University, 34134 Daejeon, South Korea.
Chul O ParkDepartment of Biological Sciences, Seoul National University, 151-747 Seoul, South Korea.
Won-Ki HuhDepartment of Biological Sciences, Seoul National University, 151-747 Seoul, South Korea.ORCID 0000-0002-9091-6594
Matthias CarlLaboratory of Translational Neurogenetics, Center for Integrative Biology, University of Trento, 38123 Trento, Italy.
Jill A RosenfeldDepartment of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX 77030.
Salmo RaskinGroup for Advanced Molecular Investigation, Health and Biosciences School, Pontifícia Universidade Católica do Paraná, 80215-901 Curitiba Paraná, Brazil.
Alan MaDepartment of Genetics, Nepean Hospital Sydney, University of Sydney, NSW 2006, Australia.
Jozef GeczSchool of Medicine and The Robinson Research Institute, University of Adelaide, Adelaide 5000, Australia.ORCID 0000-0002-7884-6861
Hyung-Goo KimDepartment of OB/GYN, Augusta University, Augusta, GA 30912.
Jin-Soo KimCenter for Genome Engineering, Institute for Basic Science, Seoul National University, 151-747 Seoul, South Korea.
Ho-Chul ShinKorea Research Institute of Bioscience and Biotechnology, 305-806 Daejeon, South Korea.
Doo-Sang ParkKorea Research Institute of Bioscience and Biotechnology, 305-806 Daejeon, South Korea.
Robert GerlaiDepartment of Psychology, University of Toronto Mississauga, Mississauga, ON L5L 1C6, Canada.
Bradley B JamiesonDepartment of Physiology, University of Otago, 9054 Dunedin, New Zealand.
Joon S KimDepartment of Physiology, University of Otago, 9054 Dunedin, New Zealand.
Karl J IremongerDepartment of Physiology, University of Otago, 9054 Dunedin, New Zealand.ORCID 0000-0002-8976-2401
Sang H LeeDepartment of Pharmacology & Toxicology, Neuroscience Research Institute, Medical College of Wisconsin, WI 53226.
Hee-Sup ShinInstitute for Basic Science School, University of Science and Technology, 34113 Daejeon, South Korea; shin@ibs.re.kr zebrakim@cnu.ac.kr.
Cheol-Hee KimDepartment of Biology, Chungnam National University, 34134 Daejeon, South Korea; shin@ibs.re.kr zebrakim@cnu.ac.kr.
Chungnam National University · KRInstitute for Basic Science · KRSeoul National University · KRUniversity of Otago · NZBaylor College of Medicine · USKorea Research Institute of Bioscience and Biotechnology · KRMedical College of Wisconsin · USPontifícia Universidade Católica do Paraná · BRSouth Australian Health and Medical Research Institute · AUThe University of Sydney · AUUniversity of Toronto · CAUniversity of Trento · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emotional responses, such as fear and anxiety, are fundamentally important behavioral phenomena with strong fitness components in most animal species. Anxiety-related disorders continue to represent a major unmet medical need in our society, mostly because we still do not fully understand the mechanisms of these diseases. Animal models may speed up discovery of these mechanisms. The zebrafish is a highly promising model organism in this field. Here, we report the identification of a chemokine-like gene family,

Indexed as

FearMutationAnimalsAnxietyAnxiety DisordersAutism Spectrum DisorderBehavior, AnimalChemokinesConditioning, PsychologicalDisease Models, AnimalFemaleGene DeletionGenetic VariationGreen Fluorescent ProteinsHomozygoteHumansChemokinesGreen Fluorescent ProteinsRNA, Messengeranxietychemokine-likefearknockoutzebrafish

Identifiers

PMID29339520
PMCPMC5798319
OpenAlexW2783539475

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.