ArticleProceedings of the National Academy of Sciences of the United States of America2018
Human airway branch variation and chronic obstructive pulmonary disease.
Registry-linked trialOpen access · bronzeAbstract readMulticenter Study
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01969344 (Subpopulations and Intermediate Outcome Measures in COPD Study), which is not on this map. Cited by 70 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 1 pooled it
10.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Subpopulations and Intermediate Outcome Measures in COPD Study
Who cites it
70 citing papers in PubMed, 1 synthesis or guideline pooled it, 127 citations in OpenAlex.
- Phenotypic spectrum ofPeerJ · 2022Pooled it
- Review
- In silico high-resolution whole lung model to predict the locally delivered dose of inhaled drugs.Communications medicine · 2026Article
- A novel quantitative method for CT assessment of bronchiectasis using AI-based airway segmentation and upper limits of normal airway caliber.Respiratory research · 2026Article
- FGF family in health and disease.Molecular biomedicine · 2026Review
- High-resolution multimodal imaging reveals spatial and temporal heterogeneity of airway mucus plugging in mice with muco-obstructive lung disease.Scientific reports · 2025Article
- Quantitative CT and COPD: cluster analysis reveals five distinct subtypes with varying exacerbation risks.BMC pulmonary medicine · 2025Article
- Clinical practice of one-lung ventilation in mainland China: a nationwide questionnaire survey.BMC anesthesiology · 2025Article
- Longitudinal study of COPD phenotypes using integrated SPECT and qCT imaging.Frontiers in physiology · 2025Article
- Experimental Full-volume Airway Approximation for Assessing Breath-dependent Regional Aerosol Deposition.Device · 2024Article
- Unraveling Dysanapsis: Genetic Insights into Airway Lung Mismatch and COPD.American journal of respiratory and critical care medicine · 2024Article
- BranchLabelNet: Anatomical Human Airway Labeling Approach using a Dividing-and-Grouping Multi-Label Classification.Medical & biological engineering & computing · 2024Article
- Airway Tree Caliber and Susceptibility to Pollution-associated Emphysema: MESA Air and Lung Studies.American journal of respiratory and critical care medicine · 2024Article
- UNSUPERVISED AIRWAY TREE CLUSTERING WITH DEEP LEARNING: THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA) LUNG STUDY.Proceedings. IEEE International Symposium on Biomedical Imaging · 2024Article
- Airway tree caliber heterogeneity and airflow obstruction among older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Exploratory Study on COPD Phenotypes and their Progression: Integrating SPECT and qCT Imaging Analysis.medRxiv : the preprint server for health sciences · 2024Article
- Investigating distributions of inhaled aerosols in the lungs of post-COVID-19 clusters through a unified imaging and modeling approach.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2024Article
- Deep learning-based bronchial tree-guided semi-automatic segmentation of pulmonary segments in computed tomography images.Quantitative imaging in medicine and surgery · 2024Article
- Dysanapsis is differentially related to lung function trajectories with distinct structural and functional patterns in COPD and variable risk for adverse outcomes.EClinicalMedicine · 2024Article
- Mucus plugs in the airways of asthmatic subjects and smoking status.Respiratory research · 2024Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors at 16 institutions in 2 countries.
Benjamin M SmithDepartment of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032; benjamin.m.smith@mcgill.ca.
Hussein TraboulsiTranslational Research in Respiratory Diseases Program, Department of Medicine, McGill University Health Centre Research Institute, Montreal, QC H4A 3J1, Canada.
John H M AustinDepartment of Radiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Ani ManichaikulCenter for Public Health Genomics, University of Virginia, Charlottesville, VA 22903.
Eric A HoffmanDepartment of Radiology, University of Iowa, Iowa City, IA 52242.
Eugene R BleeckerDepartment of Medicine, Wake Forest University, Winston-Salem, NC 27101.
Wellington V CardosoDepartment of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Christopher CooperDepartment of Medicine, University of California, Los Angeles, CA 90095.
David J CouperDepartment of Biostatistics, University of North Carolina at Chapel HIll, Chapel Hill, NC 27599.
Stephen M DashnawDepartment of Radiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Jia GuoDepartment of Biomedical Engineering, Columbia University, New York, NY 10027.
MeiLan K HanDepartment of Medicine, University of Michigan, Ann Arbor, MI 48109.
Nadia N HanselDepartment of Medicine, Johns Hopkins University, Baltimore, MD 21205.
Emlyn W HughesDepartment of Physics, Columbia University, New York, NY 10027.
David R JacobsDivision of Epidemiology and Community Public Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454.
Richard E KannerDepartment of Medicine, University of Utah, Salt Lake City, UT 84132.
Joel D KaufmanDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195.
Eric KleerupDepartment of Medicine, University of California, Los Angeles, CA 90095.
Ching-Long LinDepartment of Mechanical and Industrial Engineering, College of Engineering, University of Iowa, Iowa City, IA 52242.
Kiang LiuDepartment of Medicine, Northwestern University, Chicago, IL 60611.
Christian M Lo CascioDepartment of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Fernando J MartinezDepartment of Medicine, Weill Cornell Medical College, New York, NY 10065.
Jennifer N NguyenCenter for Public Health Genomics, University of Virginia, Charlottesville, VA 22903.
Martin R PrinceDepartment of Radiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Stephen RennardDepartment of Medicine, University of Nebraska Medical Center, Omaha, NE 68198.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA 22903.
Leora SimonTranslational Research in Respiratory Diseases Program, Department of Medicine, McGill University Health Centre Research Institute, Montreal, QC H4A 3J1, Canada.
Yanping SunDepartment of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Karol E WatsonDepartment of Medicine, University of California, Los Angeles, CA 90095.
Prescott G WoodruffDepartment of Medicine, University of California, San Francisco, CA 94110.
Carolyn J BagloleTranslational Research in Respiratory Diseases Program, Department of Medicine, McGill University Health Centre Research Institute, Montreal, QC H4A 3J1, Canada.
R Graham BarrDepartment of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
MESA Lung and SPIROMICS investigators
Columbia University · USMcGill University Health Centre · CAUniversity of California, Los Angeles · USUniversity of Virginia · USUniversity of Iowa · USCornell University · USJohns Hopkins University · USNorthwestern University · USUniversity of California, San Francisco · USUniversity of Michigan–Ann Arbor · USUniversity of Minnesota · USUniversity of Nebraska Medical Center · USUniversity of North Carolina at Chapel Hill · USUniversity of Utah · USUniversity of Washington · USWake Forest University · US
Funding
True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Steven N. Chillrud · 1998 to 2026
$44.7MPulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5MVector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Alejandro Antonio Pezzulo · 1998 to 2026
$30.5MSPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9MPulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8MPulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2MMechanisms Controlling Expansion and Lineage Specification of Airway Progenitors in Development and DiseaseR35HL135834 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CARDOSO, WELLINGTON V. · 2017 to 2023
$6.7MSUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC95161 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SHEA, STEVEN · 2007 to 2014
$6.4MSUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC95165 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BURKE, GREGORY L · 2007 to 2014
$6.3MChronic obstructive pulmonary disease in non-smokersR01HL130506 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HERBSTMAN, JULIE BETH, SMITH, BENJAMIN M. · 2016 to 2025
$6.3MSUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC95163 · NHLBI · UNIVERSITY OF MINNESOTA · PI FOLSOM, AARON R · 2007 to 2014
$6.1MNovel Quantitative Emphysema Subtypes in MESA and SPIROMICSR01HL121270 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BARR, R GRAHAM, LAINE, ANDREW FRANCIS · 2014 to 2022
$5.6MNHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS K24 HL137013NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01HC95161NHLBI NIH HHS N01HC95163NHLBI NIH HHS N01HC95165NHLBI NIH HHS N01HC95166NHLBI NIH HHS N01HC95167NHLBI NIH HHS N01HC95168NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL093081NHLBI NIH HHS R01 HL112986NHLBI NIH HHS R01 HL121270NHLBI NIH HHS R01 HL130506NHLBI NIH HHS R35 HL135834NHLBI NIH HHS RC1 HL100543NHLBI NIH HHS U01 HL114494NHLBI NIH HHS U01 HL137880NIDDK NIH HHS P30 DK054759NIEHS NIH HHS P30 ES005605NIEHS NIH HHS P30 ES009089
Abstract
Susceptibility to chronic obstructive pulmonary disease (COPD) beyond cigarette smoking is incompletely understood, although several genetic variants associated with COPD are known to regulate airway branch development. We demonstrate that in vivo central airway branch variants are present in 26.5% of the general population, are unchanged over 10 y, and exhibit strong familial aggregation. The most common airway branch variant is associated with COPD in two cohorts (
Indexed as
AgedAged, 80 and overBronchiDisease SusceptibilityFemaleFibroblast Growth Factor 10GenotypeHumansImage Processing, Computer-AssistedLungMaleMiddle AgedPhenotypePolymorphism, Single NucleotideProspective StudiesPulmonary Disease, Chronic ObstructiveFGF10 protein, humanFibroblast Growth Factor 10airway branchingchronic obstructive pulmonary diseasecomputed tomographyfibroblast growth factor
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT01969344ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.