Evidence map›Paper›PMID 29339509›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Biodegradable Piezoelectric Force Sensor.

Eli J Curry, Kai Ke, Meysam T Chorsi, Kinga S Wrobel, Albert N Miller, Avi Patel, Insoo Kim, Jianlin Feng, Lixia Yue, Qian Wu and 6 more

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 408 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Top-Down Fabricated Wood-Derived Pressure and Strain Sensors: A Review.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Piezoelectric Biomaterials for Bone Regeneration: Roadmap from Dipole to Osteogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  16. Stimuli-responsive hybrid materials for 4DMaterials today. Bio · 2025
    Review
  17. Article
  18. Review
  19. Article
  20. Article

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Eli J CurryDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269.
Kai KeDepartment of Mechanical Engineering, University of Connecticut, Storrs, CT 06269.
Meysam T ChorsiDepartment of Mechanical Engineering, University of Connecticut, Storrs, CT 06269.
Kinga S WrobelDepartment of Mechanical Engineering, University of Connecticut, Storrs, CT 06269.
Albert N MillerDepartment of Mechanical Engineering, University of Connecticut, Storrs, CT 06269.
Avi PatelDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269.
Insoo KimDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269.
Jianlin FengDepartment of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030.
Lixia YueDepartment of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030.
Qian WuDepartment of Pathology and Laboratory Medicine, University of Connecticut Health Center, Farmington, CT 06030.
Chia-Ling KuoConnecticut Institute for Clinical and Translational Science, Farmington, CT 06030.
Kevin W-H LoDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269.
Cato T LaurencinDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269.
Horea IliesDepartment of Mechanical Engineering, University of Connecticut, Storrs, CT 06269.
Prashant K PurohitDepartment of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA 19104.
Thanh D NguyenDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269; nguyentd@uconn.edu.ORCID 0000-0003-0813-4807
University of Connecticut · USUConn Health · USUniversity of Pennsylvania · US

Funding

Ca2+ signaling mechanisms in cardiac fibrosisR01HL078960 · NHLBI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI YUE, LIXIA · 2005 to 2015
$3.9M
Bionic Self-Stimulated Cartilage R21EB024787R21EB024787 · NIBIB · UNIVERSITY OF CONNECTICUT STORRS · PI NGUYEN, THANH · 2017 to 2020
$797k
NHLBI NIH HHS R01 HL078960NIBIB NIH HHS R21 EB024787
6 · The paper itself

Abstract

Measuring vital physiological pressures is important for monitoring health status, preventing the buildup of dangerous internal forces in impaired organs, and enabling novel approaches of using mechanical stimulation for tissue regeneration. Pressure sensors are often required to be implanted and directly integrated with native soft biological systems. Therefore, the devices should be flexible and at the same time biodegradable to avoid invasive removal surgery that can damage directly interfaced tissues. Despite recent achievements in degradable electronic devices, there is still a tremendous need to develop a force sensor which only relies on safe medical materials and requires no complex fabrication process to provide accurate information on important biophysiological forces. Here, we present a strategy for material processing, electromechanical analysis, device fabrication, and assessment of a piezoelectric Poly-l-lactide (PLLA) polymer to create a biodegradable, biocompatible piezoelectric force sensor, which only employs medical materials used commonly in Food and Drug Administration-approved implants, for the monitoring of biological forces. We show the sensor can precisely measure pressures in a wide range of 0-18 kPa and sustain a reliable performance for a period of 4 d in an aqueous environment. We also demonstrate this PLLA piezoelectric sensor can be implanted inside the abdominal cavity of a mouse to monitor the pressure of diaphragmatic contraction. This piezoelectric sensor offers an appealing alternative to present biodegradable electronic devices for the monitoring of intraorgan pressures. The sensor can be integrated with tissues and organs, forming self-sensing bionic systems to enable many exciting applications in regenerative medicine, drug delivery, and medical devices.

Indexed as

Absorbable ImplantsPressureAnimalsBiomechanical PhenomenaElectricityHumansMiceMonitoring, PhysiologicPolyestersPolyesterspoly(lactide)biodegradablepiezoelectricPLLApressuresensor

Identifiers

PMID29339509
PMCPMC5798324
OpenAlexW2783908655

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.