Evidence map›Paper›PMID 29339503›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology.

Pierre Vantourout, Adam Laing, Martin J Woodward, Iva Zlatareva, Luis Apolonia, Andrew W Jones, Ambrosius P Snijders, Michael H Malim, Adrian C Hayday

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 163 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Cell stress activates γ9δ2 T cells via endogenous phosphoantigens and butyrophilin complex dynamics.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Metabolic control of innate-like T cells.Nature reviews. Immunology · 2026
    Review
  9. γ9δ2 T cells detect mevalonate diphosphate via BTN3A3.Cellular and molecular life sciences : CMLS · 2025
    Article
  10. International journal of molecular sciences · 2025
    Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Investigation of structural and dynamic properties of the Butyrophilin BTN3A1/BTN2A1 cytoplasmic complex byFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Cancer immunotherapy by γδ T cells.Science (New York, N.Y.) · 2024
    Review

54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Pierre VantouroutPeter Gorer Department of Immunobiology, King's College London, London SE1 9RT, United Kingdom.
Adam LaingPeter Gorer Department of Immunobiology, King's College London, London SE1 9RT, United Kingdom.
Martin J WoodwardPeter Gorer Department of Immunobiology, King's College London, London SE1 9RT, United Kingdom.
Iva ZlatarevaPeter Gorer Department of Immunobiology, King's College London, London SE1 9RT, United Kingdom.
Luis ApoloniaDepartment of Infectious Diseases, King's College London, London SE1 9RT, United Kingdom.
Andrew W JonesMass Spectrometry Proteomics Platform, The Francis Crick Institute, London NW11AT, United Kingdom.
Ambrosius P SnijdersMass Spectrometry Proteomics Platform, The Francis Crick Institute, London NW11AT, United Kingdom.
Michael H MalimDepartment of Infectious Diseases, King's College London, London SE1 9RT, United Kingdom.ORCID 0000-0002-7699-2064
Adrian C HaydayPeter Gorer Department of Immunobiology, King's College London, London SE1 9RT, United Kingdom; adrian.hayday@kcl.ac.uk.
King's College London · GBThe Francis Crick Institute · GB

Funding

Cancer Research UK FC001093Department of Health FC001093Medical Research Council FC001093Wellcome Trust 100156/Z/12/ZWellcome Trust 106223/Z/14/ZWellcome Trust 106292/Z/14/ZWellcome Trust FC001093
6 · The paper itself

Abstract

The long-held view that gamma delta (γδ) T cells in mice and humans are fundamentally dissimilar, as are γδ cells in blood and peripheral tissues, has been challenged by emerging evidence of the cells' regulation by butyrophilin (BTN) and butyrophilin-like (BTNL) molecules. Thus, murine

Indexed as

Amino Acid MotifsAnimalsAntigens, CDButyrophilinsEndoplasmic ReticulumHEK293 CellsHumansLymphocyte ActivationMiceProtein MultimerizationReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocyte SubsetsAntigens, CDBTN3A1 protein, humanBTN3A2 protein, humanButyrophilinsReceptors, Antigen, T-Cell, gamma-deltabutyrophilinsendoplasmic reticulumevolutionary conservationgamma delta T cellszoledronate

Identifiers

PMID29339503
PMCPMC5798315
OpenAlexW2784098749

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.