ArticleProceedings of the National Academy of Sciences of the United States of America2018
Open access · bronzeAbstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
9.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 115 citations in OpenAlex.
- Genetic background modulates MafADiabetologia · 2026Article
- Insulinomatosis: A case report of a multifocal insulin-secreting entity.Radiology case reports · 2026Article
- Dual phenotype in a patient with adult-onset hyperinsulinism and diabetes caused by an activatingJournal of the Endocrine Society · 2026Article
- Review
- Multi-omic profiles of neuroendocrine neoplasms of the pancreas: an integrated landscape.Molecular cancer · 2026Review
- Differentiating well-differentiated neuroendocrine tumors grade 3 from poorly differentiated neuroendocrine carcinomas and adenocarcinoma with neuroendocrine differentiation: a comprehensive review.Virchows Archiv : an international journal of pathology · 2026Review
- Concept of neuroendocrine neoplasms of all organs with a focus on grading, subtyping.Virchows Archiv : an international journal of pathology · 2026Review
- Whole Exome Sequencing in 26 Saudi Patients Expands the Mutational and Clinical Spectrum of Diabetic Nephropathy.Medicina (Kaunas, Lithuania) · 2025Article
- Why all MODY variants in transcription factor genes are dominantly inherited.Frontiers in genetics · 2025Article
- Neuroendocrine Tumors: Germline Genetics and Hereditary Syndromes.Current treatment options in oncology · 2025Review
- Molecular Basis of Pancreatic Neuroendocrine Tumors.International journal of molecular sciences · 2024Review
- CRISPR screening uncovers a long-range enhancer for ONECUT1 in pancreatic differentiation and links a diabetes risk variant.Cell reports · 2024Article
- Generation and application of novel hES cell reporter lines for the differentiation and maturation of hPS cell-derived islet-like clusters.Scientific reports · 2024Article
- Genotype-histotype-phenotype correlations in hyperinsulinemic hypoglycemia.Histology and histopathology · 2024Review
- The Medical and Surgical Management of Recurrent Multicenter Insulinomatosis Without Known Genetic Predisposition.ACG case reports journal · 2024Article
- [Multiple neuroendocrine tumors of the pancreas].Pathologie (Heidelberg, Germany) · 2024Review
- Expanding Our Knowledge ofCancers · 2024Review
- Whole-exome sequencing in familial type 2 diabetes identifies an atypical missense variant in the RyR2 gene.Frontiers in endocrinology · 2024Article
- Modelling human diabetesFrontiers in endocrinology · 2024Review
- An Insight into Vital Genes Responsible for β-cell Formation.Advances in experimental medicine and biology · 2024Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 14 institutions in 8 countries.
Donato IacovazzoCentre for Endocrinology, Barts and The London School of Medicine, Queen Mary University of London, EC1M 6BQ London, United Kingdom.
Sarah E FlanaganInstitute of Biomedical and Clinical Science, University of Exeter Medical School, EX2 5DW Exeter, United Kingdom.
Emily WalkerDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232.
Rosana QuezadoServiço de Endocrinologia e Diabetes, Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, 60430-372 Fortaleza, Brazil.
Fernando Antonio de Sousa BarrosServiço de Endocrinologia e Diabetes, Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, 60430-372 Fortaleza, Brazil.
Richard CaswellInstitute of Biomedical and Clinical Science, University of Exeter Medical School, EX2 5DW Exeter, United Kingdom.ORCID 0000-0003-0713-4602
Matthew B JohnsonInstitute of Biomedical and Clinical Science, University of Exeter Medical School, EX2 5DW Exeter, United Kingdom.
Matthew WakelingInstitute of Biomedical and Clinical Science, University of Exeter Medical School, EX2 5DW Exeter, United Kingdom.
Michael BrändleDivision of Endocrinology and Diabetes, Department of Internal Medicine, Kantonsspital St. Gallen, CH-9007 St. Gallen, Switzerland.
Min GuoDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232.
Mary N DangCentre for Endocrinology, Barts and The London School of Medicine, Queen Mary University of London, EC1M 6BQ London, United Kingdom.
Plamena GabrovskaCentre for Endocrinology, Barts and The London School of Medicine, Queen Mary University of London, EC1M 6BQ London, United Kingdom.
Bruno NiederleSection of Endocrine Surgery, Division of General Surgery, Department of Surgery, University of Vienna, A-1090 Vienna, Austria.
Emanuel ChristDivision of Diabetes, Endocrinology and Metabolism, University Hospital of Basel, CH-4031 Basel, Switzerland.
Stefan JenniDivision of Endocrinology, Diabetes and Clinical Nutrition, University Hospital of Bern, Inselspital, CH-3010 Bern, Switzerland.
Bence SiposDepartment of Pathology, University of Tübingen, 72076 Tübingen, Germany.
Maike NieserDepartment of Pathology, University of Tübingen, 72076 Tübingen, Germany.
Andrea FrillingDepartment of Surgery and Cancer, Imperial College London, W12 0HS London, United Kingdom.
Ketan DhatariyaElsie Bertram Diabetes Centre, Norfolk and Norwich University Hospitals NHS Foundation Trust, NR4 7UY Norwich, United Kingdom.
Philippe ChansonService d'Endocrinologie et des Maladies de la Reproduction, Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, F-94275 Le Kremlin-Bicêtre, France.ORCID 0000-0001-5096-5722
Wouter W de HerderDepartment of Internal Medicine, Sector of Endocrinology, ENETS Centre of Excellence for Neuroendocrine Tumors, Erasmus MC, 3015 Rotterdam, The Netherlands.ORCID 0000-0003-1463-5165
Björn KonukiewitzDepartment of Pathology, Consultation Center for Pancreatic and Endocrine Tumors, Technical University of Munich, 81675 Munich, Germany.
Günter KlöppelDepartment of Pathology, Consultation Center for Pancreatic and Endocrine Tumors, Technical University of Munich, 81675 Munich, Germany.
Roland SteinDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232.
Márta KorbonitsCentre for Endocrinology, Barts and The London School of Medicine, Queen Mary University of London, EC1M 6BQ London, United Kingdom; m.korbonits@qmul.ac.uk.
Sian EllardInstitute of Biomedical and Clinical Science, University of Exeter Medical School, EX2 5DW Exeter, United Kingdom.
University of Exeter · GBQueen Mary University of London · GBVanderbilt University · USTechnical University of Munich · DEUniversidade Federal do Ceará · BRUniversity of Tübingen · DEErasmus MC · NLImperial College London · GBInserm · FRKantonsspital St. Gallen · CHNorfolk and Norwich University Hospitals NHS Foundation Trust · GBUniversity Hospital of Basel · CHUniversity Hospital of Bern · CHUniversity of Vienna · AT
Funding
Defining the Role of MafA in Islet Beta CellsR01DK090570 · NIDDK · VANDERBILT UNIVERSITY · PI PARENT, AUDREY, STEIN, ROLAND W · 2011 to 2025
$5.9MAnalyzing the importance of the MAFB transcription factor in human beta cell activityF32DK109577 · NIDDK · VANDERBILT UNIVERSITY · PI WALKER, EMILY M · 2016 to 2018
$174kDepartment of HealthMedical Research Council MR/M018539/1NIDDK NIH HHS F32 DK109577NIDDK NIH HHS R01 DK090570Wellcome TrustWellcome Trust 098395/Z/12/AWellcome Trust 105636/Z/14/Z
Abstract
The β-cell-enriched MAFA transcription factor plays a central role in regulating glucose-stimulated insulin secretion while also demonstrating oncogenic transformation potential in vitro. No disease-causing
Indexed as
Mutation, MissenseDiabetes MellitusExome SequencingFemaleGenes, DominantHumansHyperinsulinismInsulinomaMaf Transcription Factors, LargeMaleMutant ProteinsNeuroendocrine TumorsPancreatic NeoplasmsPedigreeProtein StabilityTranscriptional ActivationMAFA protein, humanMaf Transcription Factors, LargeMutant ProteinsdiabetesinsulinomainsulinomatosisMAFAMODY
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.