ArticleProceedings of the National Academy of Sciences of the United States of America2018
Ultrafast imaging of cell elasticity with optical microelastography.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed.
- From Cytoskeletal Remodeling to Oocyte Quality: The Emerging Role of Mechanics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Mechanobiology of the tumor microenvironment: a review of therapeutic interactions and in vitro elasticity measurement techniques.Journal of biomedical science · 2026Review
- Modeling and Validation of Oocyte Mechanical Behavior Using AFM Measurement and Multiphysics Simulation.Sensors (Basel, Switzerland) · 2025Article
- Toward quantitative X-ray elastography of coronary arteries using flexural pulse waves.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Tissue stiffness mapping by light sheet elastography.Science advances · 2025Article
- Noninvasive characterization of oocyte deformability in microconstrictions.Science advances · 2025Article
- Rapid Stiffness Mapping in Soft Biologic Tissues With Micrometer Resolution Using Optical Multifrequency Time-Harmonic Elastography.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Thoracolumbar fascia ultrasound shear strain differs between low back pain and asymptomatic individuals: expanding the evidence.Insights into imaging · 2025Article
- Full-field noise-correlation elastography for in-plane mechanical anisotropy imaging.Biomedical optics express · 2024Article
- Imaging the subcellular viscoelastic properties of mouse oocytes.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Debiased ambient vibrations optical coherence elastography to profile cell, organoid and tissue mechanical properties.Communications biology · 2023Article
- High-frequency ultrasound point-of-care device to quantify myopia-induced microstructural changes in the anterior sclera.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2023Article
- Investigation of Soft Matter Nanomechanics by Atomic Force Microscopy and Optical Tweezers: A Comprehensive Review.Nanomaterials (Basel, Switzerland) · 2023Review
- Recent advances in optical elastography and emerging opportunities in the basic sciences and translational medicine [Invited].Biomedical optics express · 2023Review
- Mechanical Characterization and Modelling of Subcellular Components of Oocytes.Micromachines · 2022Article
- Longitudinal shear wave elasticity measurements of millimeter-sized biomaterials using a single-element transducer platform.PloS one · 2022Article
- Nuclear envelope mechanobiology: linking the nuclear structure and function.Nucleus (Austin, Tex.) · 2021Review
- Time-of-flight and noise-correlation-inspired algorithms for full-field shear-wave elastography using digital holography.Journal of biomedical optics · 2021Article
- Lorentz force induced shear waves for magnetic resonance elastography applications.Scientific reports · 2021Article
- Image-Based Elastography of Heterochromatin and Euchromatin Domains in the Deforming Cell Nucleus.Small (Weinheim an der Bergstrasse, Germany) · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Elasticity is a fundamental cellular property that is related to the anatomy, functionality, and pathological state of cells and tissues. However, current techniques based on cell deformation, atomic force microscopy, or Brillouin scattering are rather slow and do not always accurately represent cell elasticity. Here, we have developed an alternative technique by applying shear wave elastography to the micrometer scale. Elastic waves were mechanically induced in live mammalian oocytes using a vibrating micropipette. These audible frequency waves were observed optically at 200,000 frames per second and tracked with an optical flow algorithm. Whole-cell elasticity was then mapped using an elastography method inspired by the seismology field. Using this approach we show that the elasticity of mouse oocytes is decreased when the oocyte cytoskeleton is disrupted with cytochalasin B. The technique is fast (less than 1 ms for data acquisition), precise (spatial resolution of a few micrometers), able to map internal cell structures, and robust and thus represents a tractable option for interrogating biomechanical properties of diverse cell types.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.