ArticleProceedings of the National Academy of Sciences of the United States of America2018
Coding of episodic memory in the human hippocampus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Reevaluating the role of the hippocampus in memory: A meta-analysis of neurotoxic lesion studies in nonhuman primates.Hippocampus · 2023Pooled it
- Enhanced brain activity associated with memory access in highly superior autobiographical memory.Proceedings of the National Academy of Sciences of the United States of America · 2018Trial
- Aging shifts hippocampal reactivation from selective reinstatement to category-level misbinding during episodic memory.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Neuronal allocation and sparse coding of episodic memories in the human hippocampus.Scientific reports · 2025Article
- Unraveling trauma memory: Differential functional connectivity profiles of anterior and posterior hippocampus in post-traumatic stress disorder and its dissociative subtype.Neuroimage. Reports · 2025Article
- Microglia Support Both the Singular Form of LTP Expressed by the Lateral Perforant Path and Episodic Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans.Nature communications · 2025Article
- Dynamic patterns of functional connectivity in the human brain underlie individual memory formation.Nature communications · 2024Article
- Variable recruitment of distal tuft dendrites shapes new hippocampal place fields.bioRxiv : the preprint server for biology · 2024Article
- Statistical learning in epilepsy: Behavioral and anatomical mechanisms in the human brain.Epilepsia · 2024Article
- On the basis of sex and sleep: the influence of the estrous cycle and sex on sleep-wake behavior.Frontiers in neuroscience · 2024Review
- Hippocampal neurons code individual episodic memories in humans.Nature human behaviour · 2023Article
- A survey and perspective on neuromorphic continual learning systems.Frontiers in neuroscience · 2023Review
- Dopamine Receptor Supports the Potentiation of Intrinsic Excitability and Synaptic LTD in Temporoammonic-CA1 Synapse.Experimental neurobiology · 2022Article
- Article
- Two kinds of memory signals in neurons of the human hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Higher-dimensional neural representations predict better episodic memory.Science advances · 2022Article
- Subcortical Brain Morphometry Differences between Adults with Autism Spectrum Disorder and Schizophrenia.Brain sciences · 2022Article
- Correctness and response time distributions in the MemTrax continuous recognition task: Analysis of strategies and a reverse-exponential model.Frontiers in aging neuroscience · 2022Article
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8 authors.
Funding
Abstract
Neurocomputational models have long posited that episodic memories in the human hippocampus are represented by sparse, stimulus-specific neural codes. A concomitant proposal is that when sparse-distributed neural assemblies become active, they suppress the activity of competing neurons (neural sharpening). We investigated episodic memory coding in the hippocampus and amygdala by measuring single-neuron responses from 20 epilepsy patients (12 female) undergoing intracranial monitoring while they completed a continuous recognition memory task. In the left hippocampus, the distribution of single-neuron activity indicated that only a small fraction of neurons exhibited strong responding to a given repeated word and that each repeated word elicited strong responding in a different small fraction of neurons. This finding reflects sparse distributed coding. The remaining large fraction of neurons exhibited a concurrent reduction in firing rates relative to novel words. The observed pattern accords with longstanding predictions that have previously received scant support from single-cell recordings from human hippocampus.
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