ArticleThe Journal of pharmacology and experimental therapeutics2018
Curcumin Acts as a Positive Allosteric Modulator of
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Article in The Journal of pharmacology and experimental therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Targeting the cholinergic and endocannabinoid systems as a therapeutic intervention for core and associated phenotypes in the autism model; a systematic review.Trends in psychiatry and psychotherapy · 2025Pooled it
- Curcumin regulates ferroptosis by activating α7 nicotinic acetylcholine receptor to improve sepsis-induced acute kidney injury.Renal failure · 2026Article
- Article
- The Role of α7-Nicotinic Acetylcholine Receptors in the Pathophysiology and Treatment of Parkinson's Disease.International journal of molecular sciences · 2025Review
- Competitive Antagonism of Xylazine on α7 Nicotinic Acetylcholine Receptors and Reversal by Curcuminoids.ACS chemical neuroscience · 2025Article
- The Role of Alpha-7 Nicotinic Acetylcholine Receptors in Pain: Potential Therapeutic Implications.Current neuropharmacology · 2025Review
- Curcumin Improves Neurogenesis in Alzheimer's Disease Mice via the Upregulation of Wnt/β-Catenin and BDNF.International journal of molecular sciences · 2024Article
- Anti-hyperalgesic and anti-inflammatory effects of 4R-tobacco cembranoid in a mouse model of inflammatory pain.Journal of inflammation (London, England) · 2024Article
- Nicotinic acetylcholine receptors: Therapeutic targets for novel ligands to treat pain and inflammation.Pharmacological research · 2023Review
- Recent Advances in the Discovery of Nicotinic Acetylcholine Receptor Allosteric Modulators.Molecules (Basel, Switzerland) · 2023Review
- Formulated Curcumin Prevents Paclitaxel-Induced Peripheral Neuropathy through Reduction in Neuroinflammation by Modulation of α7 Nicotinic Acetylcholine Receptors.Pharmaceutics · 2022Article
- Therapeutic Potential of Curcumin in Reversing the Depression and Associated Pseudodementia via Modulating Stress Hormone, Hippocampal Neurotransmitters, and BDNF Levels in Rats.Neurochemical research · 2021Article
- Neuroprotective Activities of Curcumin in Parkinson's Disease: A Review of the Literature.International journal of molecular sciences · 2021Review
- Stable desensitization of αEuropean journal of pharmacology · 2021Article
- Curcumin Potentiates α7 Nicotinic Acetylcholine Receptors and Alleviates Autistic-Like Social Deficits and Brain Oxidative Stress Status in Mice.International journal of molecular sciences · 2021Article
- Article
- Natural Polyhydroxy Flavonoids, Curcuminoids, and Synthetic Curcumin Analogs as α7 nAChRs Positive Allosteric Modulators.International journal of molecular sciences · 2021Article
- Cardioprotective role of GTS-21 by attenuating the TLR4/NF-κB pathway in streptozotocin-induced diabetic cardiomyopathy in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
- Neuroprotective Effect of Curcumin on the Nigrostriatal Pathway in a 6-Hydroxydopmine-Induced Rat Model of Parkinson's Disease is Mediated by α7-Nicotinic Receptors.International journal of molecular sciences · 2020Article
- Key Developments in the Potential of Curcumin for the Treatment of Peripheral Neuropathies.Antioxidants (Basel, Switzerland) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 4 countries.
Eslam Gaber El NebrisiDepartments of Pharmacology (E.G.E.N., H.A.S., M.O.) and Physiology (F.C.H.), College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates; Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia (D.B., W.T., A.B., Y.A., I.M.D.); Experimental Animals Breeding and Research Center, Faculty of Medicine, Uludag University, Bursa, Turkey (D.B.); Department of Biological Sciences, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, California (K.-H.S.Y.); and Department of Basic Medical Sciences, College of Medicine, Qatar University, Doha, Qatar (M.O.).
Deniz BagdasDepartments of Pharmacology (E.G.E.N., H.A.S., M.O.) and Physiology (F.C.H.), College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates; Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia (D.B., W.T., A.B., Y.A., I.M.D.); Experimental Animals Breeding and Research Center, Faculty of Medicine, Uludag University, Bursa, Turkey (D.B.); Department of Biological Sciences, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, California (K.-H.S.Y.); and Department of Basic Medical Sciences, College of Medicine, Qatar University, Doha, Qatar (M.O.).
Wisam TomaDepartments of Pharmacology (E.G.E.N., H.A.S., M.O.) and Physiology (F.C.H.), College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates; Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia (D.B., W.T., A.B., Y.A., I.M.D.); Experimental Animals Breeding and Research Center, Faculty of Medicine, Uludag University, Bursa, Turkey (D.B.); Department of Biological Sciences, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, California (K.-H.S.Y.); and Department of Basic Medical Sciences, College of Medicine, Qatar University, Doha, Qatar (M.O.).
Halima Al SamriDepartments of Pharmacology (E.G.E.N., H.A.S., M.O.) and Physiology (F.C.H.), College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates; Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia (D.B., W.T., A.B., Y.A., I.M.D.); Experimental Animals Breeding and Research Center, Faculty of Medicine, Uludag University, Bursa, Turkey (D.B.); Department of Biological Sciences, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, California (K.-H.S.Y.); and Department of Basic Medical Sciences, College of Medicine, Qatar University, Doha, Qatar (M.O.).
Anna BrodzikDepartments of Pharmacology (E.G.E.N., H.A.S., M.O.) and Physiology (F.C.H.), College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates; Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia (D.B., W.T., A.B., Y.A., I.M.D.); Experimental Animals Breeding and Research Center, Faculty of Medicine, Uludag University, Bursa, Turkey (D.B.); Department of Biological Sciences, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, California (K.-H.S.Y.); and Department of Basic Medical Sciences, College of Medicine, Qatar University, Doha, Qatar (M.O.).
Yasmin AlkhlaifDepartments of Pharmacology (E.G.E.N., H.A.S., M.O.) and Physiology (F.C.H.), College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates; Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia (D.B., W.T., A.B., Y.A., I.M.D.); Experimental Animals Breeding and Research Center, Faculty of Medicine, Uludag University, Bursa, Turkey (D.B.); Department of Biological Sciences, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, California (K.-H.S.Y.); and Department of Basic Medical Sciences, College of Medicine, Qatar University, Doha, Qatar (M.O.).
Keun-Hang Susan YangDepartments of Pharmacology (E.G.E.N., H.A.S., M.O.) and Physiology (F.C.H.), College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates; Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia (D.B., W.T., A.B., Y.A., I.M.D.); Experimental Animals Breeding and Research Center, Faculty of Medicine, Uludag University, Bursa, Turkey (D.B.); Department of Biological Sciences, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, California (K.-H.S.Y.); and Department of Basic Medical Sciences, College of Medicine, Qatar University, Doha, Qatar (M.O.).
Frank Christopher HowarthDepartments of Pharmacology (E.G.E.N., H.A.S., M.O.) and Physiology (F.C.H.), College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates; Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia (D.B., W.T., A.B., Y.A., I.M.D.); Experimental Animals Breeding and Research Center, Faculty of Medicine, Uludag University, Bursa, Turkey (D.B.); Department of Biological Sciences, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, California (K.-H.S.Y.); and Department of Basic Medical Sciences, College of Medicine, Qatar University, Doha, Qatar (M.O.).
Imad M DamajDepartments of Pharmacology (E.G.E.N., H.A.S., M.O.) and Physiology (F.C.H.), College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates; Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia (D.B., W.T., A.B., Y.A., I.M.D.); Experimental Animals Breeding and Research Center, Faculty of Medicine, Uludag University, Bursa, Turkey (D.B.); Department of Biological Sciences, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, California (K.-H.S.Y.); and Department of Basic Medical Sciences, College of Medicine, Qatar University, Doha, Qatar (M.O.).
Murat OzDepartments of Pharmacology (E.G.E.N., H.A.S., M.O.) and Physiology (F.C.H.), College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates; Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia (D.B., W.T., A.B., Y.A., I.M.D.); Experimental Animals Breeding and Research Center, Faculty of Medicine, Uludag University, Bursa, Turkey (D.B.); Department of Biological Sciences, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, California (K.-H.S.Y.); and Department of Basic Medical Sciences, College of Medicine, Qatar University, Doha, Qatar (M.O.) muratoz1@yahoo.com.
Qatar University · QAVirginia Commonwealth University Medical Center · USBursa Uludağ Üni̇versi̇tesi̇ · TRChapman University · USUnited Arab Emirates University · AE
Funding
(PQ9) Mitigation of chemotherapy induced peripheral neuropathyR01CA206028 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI DAMAJ, M. IMAD, GEWIRTZ, DAVID A. · 2016 to 2020
$1.7MNCI NIH HHS R01 CA206028
Abstract
Effects of curcumin, a major ingredient of turmeric, were tested on the function of the
Indexed as
Allosteric Regulationalpha7 Nicotinic Acetylcholine ReceptorAnimalsBenzamidesBridged Bicyclo CompoundsCurcuminDisease Models, AnimalFemaleInflammationMaleMiceMotor ActivityNociceptionPainalpha7 Nicotinic Acetylcholine ReceptorBenzamidesBridged Bicyclo CompoundsCurcuminPNU-282987
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.