Evidence map›Paper›PMID 29339447›Full record

ArticleThe Journal of experimental medicine2018

Guidance of super-enhancers in regulation of IL-9 induction and airway inflammation.

Xiang Xiao, Yihui Fan, Junhui Li, Xiaolong Zhang, Xiaohua Lou, Yaling Dou, Xiaomin Shi, Peixiang Lan, Yue Xiao, Laurie Minze and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
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  11. Article
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  13. Review
  14. BRD4 as a Therapeutic Target in Pulmonary Diseases.International journal of molecular sciences · 2023
    Review
  15. The World according to IL-9.Journal of immunology (Baltimore, Md. : 1950) · 2023
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. The Role of CD4International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Xiang XiaoImmunobiology and Transplant Science Center, Houston Methodist Hospital, Texas Medical Center, Houston, TX.
Yihui FanImmunobiology and Transplant Science Center, Houston Methodist Hospital, Texas Medical Center, Houston, TX.
Junhui LiImmunobiology and Transplant Science Center, Houston Methodist Hospital, Texas Medical Center, Houston, TX.
Xiaolong ZhangImmunobiology and Transplant Science Center, Houston Methodist Hospital, Texas Medical Center, Houston, TX.
Xiaohua LouImmunobiology and Transplant Science Center, Houston Methodist Hospital, Texas Medical Center, Houston, TX.ORCID 0000-0002-8864-0912
Yaling DouImmunobiology and Transplant Science Center, Houston Methodist Hospital, Texas Medical Center, Houston, TX.
Xiaomin ShiImmunobiology and Transplant Science Center, Houston Methodist Hospital, Texas Medical Center, Houston, TX.
Peixiang LanImmunobiology and Transplant Science Center, Houston Methodist Hospital, Texas Medical Center, Houston, TX.
Yue XiaoImmunobiology and Transplant Science Center, Houston Methodist Hospital, Texas Medical Center, Houston, TX.
Laurie MinzeImmunobiology and Transplant Science Center, Houston Methodist Hospital, Texas Medical Center, Houston, TX.
Xian Chang LiImmunobiology and Transplant Science Center, Houston Methodist Hospital, Texas Medical Center, Houston, TX xcli@houstonmethodist.org.ORCID 0000-0002-5981-2762
Houston Methodist · US

Funding

Control of Treg exhaustion by OX40R01AI106200 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI LI, XIAN CHANG · 2014 to 2025
$4.2M
T cell fate decisions and transplant outcomesR01AI129906 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI LI, XIAN CHANG · 2018 to 2022
$1.9M
NIAID NIH HHS R01 AI106200NIAID NIH HHS R01 AI129906
6 · The paper itself

Abstract

Th9 cells are prominently featured in allergic lung inflammation, but the mechanism that regulates IL-9 induction in T helper cells remains poorly defined. Here we demonstrate that formation of super-enhancers (SEs) is critical in robust induction of IL-9 and that assembly of the

Indexed as

AcetylationAnimalsAsthmaEnhancer Elements, GeneticHistone CodeHumansInflammationInterleukin-9MiceMice, TransgenicMultigene FamilyPneumoniaReceptors, OX40Signal TransductionT-Lymphocytes, Helper-InducerT-Lymphocyte SubsetsInterleukin-9Receptors, OX40Relb protein, mouseTnfrsf4 protein, mouseTranscription Factor RelB

Identifiers

PMID29339447
PMCPMC5789412
OpenAlexW2783375712

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.