Evidence map›Paper›PMID 29339436›Full record

ArticleThe Journal of cell biology2018

Rewired Notch/p53 by Numb'ing Mdm2.

Hyungsoo Kim, Ze'ev A Ronai

Open access · bronzeAbstract readComment
In one paragraph

Article in The Journal of cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. [Advances in research of Musashi2 in solid tumors].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022
    Review
  7. Asymmetric Cell Division and Tumor Heterogeneity.Frontiers in cell and developmental biology · 2022
    Review
  8. Article
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Hyungsoo KimSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA hkim@sbpdiscovery.org.
Ze'ev A RonaiSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA zeev@ronailab.net.ORCID 0000-0002-3859-0400
Sanford Burnham Prebys Medical Discovery Institute · USTechnion – Israel Institute of Technology · IL

Funding

Rewired Signaling at the Nexus of Melanoma Metastasis and ResistanceR35CA197465 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI RONAI, ZEEV A. · 2016 to 2022
$7.9M
NCI NIH HHS R35 CA197465
6 · The paper itself

Abstract

Although numerous pathways are known to control the tumor suppressor protein p53, coordinated regulation of the p53-Notch axis by Numb may have an even more remarkable impact. In this issue, Colaluca at al. (2018.

Indexed as

Breast NeoplasmsTumor Suppressor Protein p53HumansMembrane ProteinsNerve Tissue ProteinsProtein IsoformsProto-Oncogene Proteins c-mdm2MDM2 protein, humanMembrane ProteinsNerve Tissue ProteinsProtein IsoformsProto-Oncogene Proteins c-mdm2Tumor Suppressor Protein p53

Identifiers

PMID29339436
PMCPMC5800819
OpenAlexW2784112737

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.