Evidence map›Paper›PMID 29339431›Full record

ArticlemBio2018

Molecular Insights into Function and Competitive Inhibition of

Tomoe Kitao, Francois Lepine, Seda Babloudi, Frederick Walte, Stefan Steinbacher, Klaus Maskos, Michael Blaesse, Michele Negri, Michael Pucci, Bob Zahler and 2 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. MvfR ShapesCells · 2025
    Article
  5. Review
  6. Anti-Biofilm Agents to OvercomePharmaceuticals (Basel, Switzerland) · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Design, Synthesis, and Evaluation of New 1Journal of medicinal chemistry · 2024
    Article
  11. Marine-Derived Furanones Targeting Quorum-Sensing Receptors inBioinformatics and biology insights · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Drug Repurposing TargetingAntibiotics (Basel, Switzerland) · 2022
    Article
  18. Treatment ofFrontiers in microbiology · 2022
    Review
  19. Pseudomonas aeruginosa Quorum Sensing.Advances in experimental medicine and biology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Tomoe KitaoDepartment of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Francois LepineINRS, Institut Armand Frappier, Laval, Québec, Canada.
Seda BabloudiDepartment of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Frederick WalteDepartment of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Stefan SteinbacherProteros Biostructures, Planegg-Martinsried, Germany.
Klaus MaskosProteros Biostructures, Planegg-Martinsried, Germany.
Michael BlaesseProteros Biostructures, Planegg-Martinsried, Germany.
Michele NegriMicrobiology Unit, Aptuit Centre of Drug Discovery and Development, Verona, Italy.
Michael PucciSpero Therapeutics, Cambridge, Massachusetts, USA.
Bob ZahlerSpero Therapeutics, Cambridge, Massachusetts, USA.
Antonio FeliciMicrobiology Unit, Aptuit Centre of Drug Discovery and Development, Verona, Italy.
Laurence G RahmeDepartment of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA rahme@molbio.mgh.harvard.edu.
Massachusetts General Hospital · USAptuit (Italy) · ITSpero Therapeutics (United States) · USHarvard University · USInstitut National de la Recherche Scientifique · CA

Funding

Function of MVFR in Pseudomonas aeruginosa virulenceR01AI063433 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RAHME, LAURENCE G · 2006 to 2010
$1.9M
Interruption of Signaling-Mediated Bacterial Persistent InfectionsR33AI105902 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RAHME, LAURENCE G · 2015 to 2017
$1.8M
Interruption of Signaling-Mediated Bacterial Persistent InfectionsR21AI105902 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RAHME, LAURENCE G · 2013 to 2014
$478k
Function of MVFR in Pseudomonas Aeruginosa VirulenceR56AI063433 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RAHME, LAURENCE G · 2012 to 2012
$475k
NIAID NIH HHS R01 AI063433NIAID NIH HHS R21 AI105902NIAID NIH HHS R33 AI105902NIAID NIH HHS R56 AI063433
6 · The paper itself

Abstract

New approaches to antimicrobial drug discovery are urgently needed to combat intractable infections caused by multidrug-resistant (MDR) bacteria.

Indexed as

Bacterial ProteinsBenzimidazolesBinding SitesCrystallography, X-RayEnzyme InhibitorsModels, MolecularProtein BindingProtein ConformationPseudomonas aeruginosaSurface Plasmon ResonanceVirulence FactorsBacterial ProteinsBenzimidazolesEnzyme InhibitorsVirulence Factorsantivirulencebenzamine-benzimidazole inhibitorscompetitive inhibitioninfectioninhibitionMvfRpathogenesisPqsRPseudomonas aeruginosaquorum sensingstructural analysisX-ray crystallography

Identifiers

PMID29339431
PMCPMC5770554
OpenAlexW2782573178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.