Evidence map›Paper›PMID 29339396›Full record

ArticleAntimicrobial agents and chemotherapy2018

Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model.

Anthony D Kang, Kenneth P Smith, Anders H Berg, Katherine A Truelson, George M Eliopoulos, Christopher McCoy, James E Kirby

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. OvercomingFrontiers in microbiology · 2024
    Article
  6. Heliyon · 2023
    Article
  7. In vitro activities of omadacycline, eravacycline, cefiderocol, apramycin, and comparator antibiotics against Acinetobacter baumannii causing bloodstream infections in Greece, 2020-2021: a multicenter study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023
    Article
  8. Synthesis of 4-Tetrahedron · 2023
    Article
  9. Article
  10. Synthesis, Antibacterial and Antiribosomal Activity of the 3Antibiotics (Basel, Switzerland) · 2022
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. New strategies and structural considerations in development of therapeutics for carbapenem-resistant Enterobacteriaceae.Translational research : the journal of laboratory and clinical medicine · 2020
    Review
  18. Review
  19. Apralogs: Apramycin 5-Journal of the American Chemical Society · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Anthony D KangDepartment of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
Kenneth P SmithDepartment of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
Anders H BergDepartment of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
Katherine A TruelsonDepartment of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
George M EliopoulosDivision of Infectious Diseases, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
Christopher McCoyDepartment of Pharmacy, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
James E KirbyDepartment of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA jekirby@bidmc.harvard.edu.
Beth Israel Deaconess Medical Center · USHarvard University · USUnited States Army · US

Funding

Identification and Characterization of Novel Antimicrobial Adjunctives to Restore Susceptibility to Carbapenem Resistant EnterobacteriaceaeF32AI124590 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SMITH, KENNETH PATRICK · 2017 to 2019
$175k
NIAID NIH HHS F32 AI124590
6 · The paper itself

Abstract

Apramycin, an aminocyclitol aminoglycoside, was rapidly bactericidal against

Indexed as

Acinetobacter baumanniiAnimalsAnti-Bacterial AgentsDrug Resistance, Multiple, BacterialMiceMicrobial Sensitivity TestsNebramycinThighAnti-Bacterial AgentsapramycinNebramycinantimicrobialapramycinmaximum tolerated dosemouse thigh modelpharmacodynamicspharmacokineticsresistancetime-kill

Identifiers

PMID29339396
PMCPMC5913965
OpenAlexW2791367131

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.