Evidence map›Paper›PMID 29339388›Full record

ArticleAntimicrobial agents and chemotherapy2018

Combating Carbapenem-Resistant Acinetobacter baumannii by an Optimized Imipenem-plus-Tobramycin Dosage Regimen: Prospective Validation via Hollow-Fiber Infection and Mathematical Modeling.

Cornelia B Landersdorfer, Rajbharan Yadav, Kate E Rogers, Tae Hwan Kim, Beom Soo Shin, John D Boyce, Roger L Nation, Jürgen B Bulitta

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Using machine learning to optimize antibiotic combinations: dosing strategies for meropenem and polymyxin B against carbapenem-resistant Acinetobacter baumannii.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2020
    Article
  4. Article
  5. Review
  6. Pharmacodynamic Drug-Drug Interactions.Clinical pharmacology and therapeutics · 2019
    Review
  7. Generating Robust and Informative NonclinicalAntimicrobial agents and chemotherapy · 2019
    Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cornelia B Landersdorfer *Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia cornelia.landersdorfer@monash.edu jbulitta@cop.ufl.edu.
Rajbharan Yadav *Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Kate E RogersDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Tae Hwan KimCenter for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, Florida, USA.
Beom Soo ShinSchool of Pharmacy, Sungkyunkwan University, Jangan-gu, Suwon, South Korea.
John D BoyceInfection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne, Australia.ORCID 0000-0002-8614-3074
Roger L NationDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Jürgen B Bulitta *Center for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, Florida, USA cornelia.landersdorfer@monash.edu jbulitta@cop.ufl.edu.ORCID 0000-0001-7352-3097

Funding

Next-generation combination dosing strategies to combat resistant Acinetobacter baumanniiR01AI130185 · NIAID · UNIVERSITY OF FLORIDA · PI BULITTA, JURGEN BERND · 2018 to 2022
$3.4M
NIAID NIH HHS R01 AI130185
6 · The paper itself

Abstract

We aimed to prospectively validate an optimized combination dosage regimen against a clinical carbapenem-resistant

Indexed as

Models, TheoreticalAcinetobacter baumanniiAnti-Bacterial AgentsCarbapenemsImipenemMicrobial Sensitivity TestsTobramycinAnti-Bacterial AgentsCarbapenemsImipenemTobramycinAcinetobacter baumanniicarbapenem resistancedynamic hollow-fiber infection modelmathematical modelingmechanism basedmechanisticpharmacodynamicspharmacokineticssynergy

Identifiers

PMID29339388
PMCPMC5913956

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.