Evidence map›Paper›PMID 29339387›Full record

ArticleAntimicrobial agents and chemotherapy2018

Genetic Basis of Emerging Vancomycin, Linezolid, and Daptomycin Heteroresistance in a Case of Persistent Enterococcus faecium Bacteremia.

Kieran I Chacko, Mitchell J Sullivan, Colleen Beckford, Deena R Altman, Brianne Ciferri, Theodore R Pak, Robert Sebra, Andrew Kasarskis, Camille L Hamula, Harm van Bakel

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Linezolid in the Focus of Antimicrobial Resistance ofInternational journal of molecular sciences · 2025
    Review
  6. Review
  7. The Impact ofPathogens (Basel, Switzerland) · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Genome Plasticity ofInfection and immunity · 2018
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Kieran I ChackoIcahn Institute for Genomics and Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-1024-4063
Mitchell J SullivanIcahn Institute for Genomics and Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Colleen BeckfordIcahn Institute for Genomics and Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Deena R AltmanDivision of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Brianne CiferriIcahn Institute for Genomics and Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Theodore R PakIcahn Institute for Genomics and Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-1676-2523
Robert SebraIcahn Institute for Genomics and Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Andrew KasarskisIcahn Institute for Genomics and Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Camille L HamulaDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Harm van BakelIcahn Institute for Genomics and Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA harm.vanbakel@mssm.edu.ORCID 0000-0002-1376-6916
Icahn School of Medicine at Mount Sinai · US

Funding

TRAINING PROGRAM: MECHANISMS OF VIRUS-HOST INTERACTIONST32AI007647 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI Domenico Tortorella · 2000 to 2026
$11.5M
Investigating genomic factors and microbiome features that impact CDI transmission and prognosisR01AI119145 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BASHIR, ALI M, VAN BAKEL, HARM · 2015 to 2019
$4.2M
MSHS Translational Science HubKL2TR001435 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MOSKOWITZ, ALAN J · 2015 to 2019
$3.8M
Transforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9M
Multiscale analysis of immune profiling data from dengue and chikungunya virus infections in humansF30AI122673 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PAK, THEODORE ROBERTSON · 2016 to 2018
$132k
NCATS NIH HHS KL2 TR001435NIAID NIH HHS F30 AI122673NIAID NIH HHS R01 AI119145NIAID NIH HHS T32 AI007647NIH HHS S10 OD018522
6 · The paper itself

Abstract

Whole-genome sequencing was used to examine a persistent

Indexed as

AgedBacteremiaDaptomycinDrug Resistance, Multiple, BacterialDrug Therapy, CombinationEnterococcus faeciumHumansLinezolidMaleMicrobial Sensitivity TestsVancomycinVancomycin ResistanceDaptomycinLinezolidVancomycindaptomycinE. faeciumfabFheteroresistancelinezolidvancomycinVRE

Identifiers

PMID29339387
PMCPMC5913925
OpenAlexW2783910820

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.