Evidence map›Paper›PMID 29339385›Full record

ArticleAntimicrobial agents and chemotherapy2018

A Before-and-After Study of the Effectiveness of an Antimicrobial Stewardship Program in Critical Care.

Francisco Álvarez-Lerma, Santiago Grau, Daniel Echeverría-Esnal, Montserrat Martínez-Alonso, María Pilar Gracia-Arnillas, Juan Pablo Horcajada, Juan Ramón Masclans

Registry-linked trialAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04848883 (Infectious Diseases Experts as Part of the Antibiotic Stewardship Team in Primary Care), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04848883 nacompletednot on this mapstarted 2021, after this paper: background citation

Infectious Diseases Experts as Part of the Antibiotic Stewardship Team in Primary Care: a Cluster-randomised Blinded Study (IDASP)

TypeinterventionalSponsorInstitut d'Investigació Biomèdica de BellvitgeRan2021 to 2024Enrolled1,389ConditionsInfectious DiseaseArmsAdvanced AMS program, Standard AMS program
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. [Antimicrobial stewardship program in an Intensive Care Unit: A retrospective observational analysis of the results 15 months after its implementation].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2023
    Observational
  6. Article
  7. Antimicrobial resistance in Gram-negative bacilli in Spain: an experts' view.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Observational
  14. Clinical impact of accepting or rejecting a recommendation from a clinical decision support system-assisted antibiotic stewardship program.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Strategies to effect change in the ICU.Current opinion in critical care · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Francisco Álvarez-LermaServicio de Medicina Intensiva, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain falvarez@parcdesalutmar.cat.
Santiago GrauServicio de Farmacia, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain.
Daniel Echeverría-EsnalServicio de Farmacia, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain.
Montserrat Martínez-AlonsoUnit of Biostatistics, Institut de Recerca Biomèdica de Lleida (IRBLLEIDA) and Department of Basic Medical Sciencies, Universitat de Lleida, Lleida, Spain.
María Pilar Gracia-ArnillasServicio de Medicina Intensiva, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain.
Juan Pablo HorcajadaUniversitat Pompeu Fabra, Barcelona, Spain.
Juan Ramón MasclansServicio de Medicina Intensiva, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We evaluated the use of antimicrobials expressed as defined daily doses (DDDs) per 1,000 patient days and days of therapy (DOT) per 100 occupied bed-days in a intensive care unit (ICU) of a general hospital in Barcelona, Spain, before and after implementation of an antimicrobial stewardship (AMS) program (2007 to 2010 versus 2011 to 2015). The quarterly costs of antimicrobials used in the ICU and its weight in the overall hospital costs of antimicrobials were calculated. The effect of the applied AMS program on DDDs and DOT time series data was analyzed by means of intervention time series analysis. A total of 5,002 patients were included (1,971 for the first [before] period and 3,031 for the second [after] period). The percentage of patients treated with one or more antimicrobials decreased from 88.6 to 77.2% (

Indexed as

Antimicrobial StewardshipAnti-Bacterial AgentsCritical CareHospitalsIntensive Care UnitsAnti-Bacterial Agentsantimicrobial agentsantimicrobialsantimicrobial stewardshipdrug costshospital costsICUintensive carestewardship program

Identifiers

PMID29339385
PMCPMC5913992

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.