Evidence map›Paper›PMID 29339260›Full record

ReviewThe Journal of allergy and clinical immunology2018

The complement system in the airway epithelium: An overlooked host defense mechanism and therapeutic target?

Hrishikesh S Kulkarni, M Kathryn Liszewski, Steven L Brody, John P Atkinson

Open access · greenAbstract readEditorialReview
In one paragraph

Review in The Journal of allergy and clinical immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 74 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Primary Amoebic Meningoencephalitis caused by Complement C2 Deficiency.medRxiv : the preprint server for health sciences · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Glycan recognition by collectin-11 drives SARS-CoV-2 infectivity and membrane injury of respiratory epithelial cells.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Divergent roles for complement components C3 and C4 in controllingbioRxiv : the preprint server for biology · 2025
    Article
  12. Emerging roles for complement in lung transplantation.The Journal of clinical investigation · 2025
    Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Hrishikesh S KulkarniDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University in St Louis, St Louis, Mo; Division of Rheumatology, Department of Medicine, Washington University in St Louis, St Louis, Mo.
M Kathryn LiszewskiDivision of Rheumatology, Department of Medicine, Washington University in St Louis, St Louis, Mo.
Steven L BrodyDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University in St Louis, St Louis, Mo.
John P AtkinsonDivision of Rheumatology, Department of Medicine, Washington University in St Louis, St Louis, Mo. Electronic address: j.p.atkinson@wustl.edu.
Washington University in St. Louis · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
PRINCIPLES IN PULMONARY RESEARCHT32HL007317 · NHLBI · WASHINGTON UNIVERSITY · PI Steven Brody, Michael J Holtzman · 1985 to 2026
$16.1M
Viral Discovery in Rheumatoid ArthritisP30AR048335 · NIAMS · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 2001 to 2015
$8.9M
TRAINING IN THE IMMUNOLOGY OF RHEUMATIC DISEASEST32AR007279 · NIAMS · WASHINGTON UNIVERSITY · PI Megan Anne Cooper, Deborah J Lenschow · 1986 to 2026
$6.0M
Complement Receptor One (CRI): Structure/FunctionR01AI041592 · NIAID · WASHINGTON UNIVERSITY · PI ATKINSON, JOHN · 1997 to 2013
$3.9M
INTRACELLULAR C3 PROTEINS: SOURCE, COMPOSITION, TRAFFICKING AND FUNCTIONR01GM099111 · NIGMS · WASHINGTON UNIVERSITY · PI ATKINSON, JOHN · 2011 to 2019
$2.7M
ROLE OF MYB FOR AIRWAY EPITHELIAL CELL DIFFERENTIATIONR01HL122582 · NHLBI · WASHINGTON UNIVERSITY · PI BRODY, STEVEN · 2015 to 2018
$1.5M
Early events regulating post-viral immunopathologyR56HL122585 · NHLBI · DARTMOUTH COLLEGE · PI ENELOW, RICHARD I · 2015 to 2015
$405k
Complement Activation Signatures in Systemic Lupus Erythematosus: Castle StudyR21AR069833 · NIAMS · WASHINGTON UNIVERSITY · PI ATKINSON, JOHN, KIM, ALFRED HYOUNGJU · 2017 to 2018
$369k
NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NHLBI NIH HHS R01 HL122582NHLBI NIH HHS R56 HL122585NHLBI NIH HHS T32 HL007317NIAID NIH HHS R01 AI041592NIAMS NIH HHS P30 AR048335NIAMS NIH HHS R21 AR069833NIAMS NIH HHS T32 AR007279NIGMS NIH HHS R01 GM099111
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAsthmaComplement System ProteinsHumansRespiratory MucosaRespiratory SystemComplement System Proteinsallergic rhinitisanaphylatoxinsasthmabronchiolitisComplementcystic fibrosisepithelial cellsovalbuminproperdinpulmonary fibrosis

Identifiers

PMID29339260
PMCPMC5955701
OpenAlexW2782783749

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.