ReviewNanomedicine : nanotechnology, biology, and medicine2018
Systemic and local toxicity of metal debris released from hip prostheses: A review of experimental approaches.
Review in Nanomedicine : nanotechnology, biology, and medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cobalt-Induced Cardiomyopathy: Mitochondrial Dysfunction, Oxidative Stress, and Reversible Cardiac Toxicity: A Systematic Review.Cardiovascular toxicology · 2026Pooled it
- Titanium and Other Metal Hypersensitivity Diagnosed by MELISA® Test: Follow-Up Study.BioMed research international · 2021Trial
- Cobalt and titanium levels in the brain are associated with Alzheimer's disease pathology but not cognition: A study of older adults with and without total joint replacement.Acta biomaterialia · 2026Article
- Toxicological Assessment of Cobalt-Chromium Dental Alloys: Ion Release, Cytotoxicity, and Possible Systemic Effects.Biological trace element research · 2026Article
- The Effect of Implant Size on Fretting Currents of Acetabular Cup-Liner Tapers During in Vitro Cyclic Loading.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- The Influence of the Type of Metal-on-Metal Hip Endoprosthesis on the Clinical, Biochemical, and Oxidative Balance Status-A Comparison of Resurfacing and Metaphyseal Implants.Nanomaterials (Basel, Switzerland) · 2025Article
- Target Organs of Metals Released from Metal-on-Polyethylene Knee and Hip Arthroplasty Implants: Implications for Tissue Metal Profiles.Biological trace element research · 2025Article
- A Comparative Analysis of In Vivo-Generated and Artificial CoCrMo Wear Particles Created by High-Energy Ball Milling and the Buchhorn Method.Materials (Basel, Switzerland) · 2025Article
- Magnetic Polymeric Conduits in Biomedical Applications.Micromachines · 2025Review
- Metal semiconductor materials in bone diseases: properties, applications, and future perspectives.Burns & trauma · 2025Review
- 3D-printed hip prostheses with regenerative integration: a state-of-the-art comprehensive review.Frontiers in bioengineering and biotechnology · 2025Review
- Hematological Response to Particle Debris Generated During Wear-Corrosion Processes of CoCr Surfaces Modified with Graphene Oxide and Hyaluronic Acid for Joint Prostheses.Nanomaterials (Basel, Switzerland) · 2024Article
- Article
- Interfaces between Cranial Bone and AISI 304 Steel after Long-Term Implantation: A Case Study of Cranial Screws.ACS biomaterials science & engineering · 2024Article
- Under-reporting by surgical pathologists in tissue removed during revision surgery for metal-on-metal arthroplasties.Annals of medicine and surgery (2012) · 2024Article
- Titanium Nitride Coatings on CoCrMo and Ti6Al4V Alloys: Effects on Wear and Ion Release.Lubricants (Basel, Switzerland) · 2024Article
- Systemic Cobalt Toxicity Secondary to Metal-on-Metal Prosthetic Hip Replacement: a Case Report.Journal of general internal medicine · 2024Article
- Influence of metallic particles and TNF on the transcriptional regulation of NLRP3 inflammasome-associated genes in human osteoblasts.Frontiers in immunology · 2024Article
- Prosthetic Metals: Release, Metabolism and Toxicity.International journal of nanomedicine · 2024Review
- Translational Characterization of Macrophage Responses to Stable and Non-Stable CoCrMo Wear and Corrosion Debris Generated In-Situ for Total Hip Replacement.Biotribology (Oxford) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Despite the technological improvements in orthopedic joint replacement implants, wear and corrosion products associated with the metal components of these implants may result in adverse local tissue and perhaps systemic reactions and toxicities. The current review encompasses a literature review of the local and systemic toxicity studies concerning the effect of CoCrMo wear debris released from wear and corrosion of orthopedic implants and prostheses. Release of metallic debris is mainly in the form of micro- and nano-particles, ions of different valences, and oxides composed of Co and Cr. Though these substances alter human biology, their direct effects of these substances on specific tissue types remain poorly understood. This may partially be the consequence of the multivariate research methodologies employed, leading to inconsistent reports. This review proposes the importance of developing new and more appropriate in-vitro methodologies to study the cellular responses and toxicity mediated by joint replacement wear debris in-vivo.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.