Evidence map›Paper›PMID 29339138›Full record

ArticleVascular pharmacology2018

Hyperglycaemia disrupts conducted vasodilation in the resistance vasculature of db/db mice.

Hamish A L Lemmey, Xi Ye, Hong C Ding, Christopher R Triggle, Christopher J Garland, Kim A Dora

Open access · hybridAbstract read
In one paragraph

Article in Vascular pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Impact of aging on vascular ion channels: perspectives and knowledge gaps across major organ systems.American journal of physiology. Heart and circulatory physiology · 2023
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Functional Interaction among KInternational journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Hamish A L LemmeyDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK. Electronic address: hamish.lemmey@magd.ox.ac.uk.
Xi YeDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK. Electronic address: xi.ye@pharm.ox.ac.uk.
Hong C DingDepartment of Pharmacology, Weill Cornell Medicine in Qatar, P.O. Box 24144, Education City, Doha, Qatar. Electronic address: hod2005@qatar-med.cornell.edu.
Christopher R TriggleDepartment of Pharmacology, Weill Cornell Medicine in Qatar, P.O. Box 24144, Education City, Doha, Qatar. Electronic address: cht2011@qatar-med.cornell.edu.
Christopher J GarlandDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK. Electronic address: christopher.garland@pharm.ox.ac.uk.
Kim A DoraDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK. Electronic address: kim.dora@pharm.ox.ac.uk.
Mansfield University · USUniversity of Oxford · GBWeill Cornell Medical College in Qatar · QA

Funding

British Heart Foundation FS/13/16/30199British Heart Foundation PG/14/58/30998British Heart Foundation PG/18/11/33552
6 · The paper itself

Abstract

Vascular dysfunction in small resistance arteries is observed during chronic elevations in blood glucose. Hyperglycaemia-associated effects on endothelium-dependent vasodilation have been well characterized, but effects on conducted vasodilation in the resistance vasculature are not known. Small mesenteric arteries were isolated from healthy and diabetic db/db mice, which were used as a model of chronic hyperglycaemia. Endothelium-dependent vasodilation via the G

Indexed as

AnimalsBlood GlucoseCalciumDiabetes Mellitus, ExperimentalEndothelial CellsEndothelium, VascularGlucoseHyperglycemiaMannitolMesenteric ArteriesMiceOligopeptidesVasodilationBlood GlucoseCalciumGlucoseMannitolOligopeptidesseryl-leucyl-isoleucyl-glycyl-arginyl-leucineConducted vasodilationDb/db miceEDHHyperglycaemiaResistance arteries

Identifiers

PMID29339138
PMCPMC5906692
OpenAlexW2783761195

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.