Evidence map›Paper›PMID 29339111›Full record

ReviewUrology2018

Stem Cells for Urinary Incontinence: Functional Differentiation or Cytokine Effects?

Bradley C Gill, Daniel Z Sun, Margot S Damaser

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Urology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Bradley C GillDepartment of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH; Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, OH; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
Daniel Z SunDepartment of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
Margot S DamaserDepartment of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH; Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, OH; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH; Advanced Platform Technology Center, Louis Stokes Cleveland VA Medical Center, Cleveland, OH. Electronic address: damsem@ccf.org.
Cleveland Clinic · US

Funding

Stem Cell Homing for Treatment of Female Pelvic Floor DisordersR01HD059859 · NICHD · CLEVELAND CLINIC LERNER COM-CWRU · PI DAMASER, MARGOT S. · 2010 to 2014
$1.6M
Regenerative Adjuvant Therapy for Stress Urinary IncontinenceI01RX000228 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI DAMASER, MARGOT S. · 2011 to 2014
–
NICHD NIH HHS R01 HD059859ORD VA F9261-LRRD VA I01 RX000228
6 · The paper itself

Abstract

Minimally invasive stem cell therapy for stress urinary incontinence may provide an effective nonsurgical treatment for this common condition. Clinical trials of periurethral stem cell injection have been under way, and basic science research has demonstrated the efficacy of both local and systemic stem cell therapies. Results differ as to whether stem cells have a therapeutic effect by differentiating into permanent, functional tissues or exert benefits through a transient presence and the secretion of regenerative factors. This review explores the fate of therapeutic stem cells for stress urinary incontinence and how this may relate to their mechanism of action.

Indexed as

Cell DifferentiationCytokinesHumansStem CellsStem Cell TransplantationUrinary Incontinence, StressCytokines

Identifiers

PMID29339111
PMCPMC6345159
OpenAlexW2782998465

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.