Evidence map›Paper›PMID 29338698›Full record

SynthesisBMC gastroenterology2018

Enteral immunonutrition versus enteral nutrition for gastric cancer patients undergoing a total gastrectomy: a systematic review and meta-analysis.

Ying Cheng, Junfeng Zhang, Liwei Zhang, Juan Wu, Zhen Zhan

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 12 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 12 syntheses or guidelines pooled it, 93 citations in OpenAlex.

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  3. The use of preoperative enteral immunonutrition in patients undergoing elective colorectal cancer surgery: A systematic review and meta-analysis.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ying ChengSchool of medicine and life sciences, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing, China.
Junfeng ZhangSchool of medicine and life sciences, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing, China.
Liwei ZhangSchool of medicine and life sciences, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing, China.
Juan WuSchool of medicine and life sciences, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing, China. wujuan1213@njucm.edu.cn.
Zhen ZhanSchool of medicine and life sciences, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing, China. zhanzhan5607@163.com.
Nanjing University of Chinese Medicine · CN

Funding

National Natural Science Foundation 81473458National Natural Science Foundation 81473593
6 · The paper itself

Abstract

backgroundNutrition support is a common means for patients with gastric cancer, especially for those undergoing elective surgery. Recently, enteral immunonutrition (EIN) was increasingly found to be more effective than enteral nutrition (EN) in enhancing the host immunity and eventually improving the prognosis of gastric cancer patients undergoing gastrectomy. However, the results reported were not consistent. This meta-analysis aimed to assess the impact of EIN for patients with GC on biochemical, immune indices and clinical outcomes.

methodsFour electronical databases (Medline, EMBASE, Scopus and Cochrane library) were used to search articles in peer-reviewed, English-language journals. Mean difference (MD), Relative risk (RR), or standard mean difference (SMD) with 95% confidence interval (CI) were calculated. Heterogeneity was assessed by Cochrane Q and I

resultsSeven studies involving 583 patients were eligible for the pooled analysis. EIN, when beyond a 7-day time-frame post-operatively (D ≥ 7), increased level of CD4

conclusionsEIN was found to improve the cellular immunity, modulate inflammatory reaction and reduce postoperative complication for GC patients undergoing radical gastrointestinal surgery. Exclusion of grey literature and non-English language studies was the key limitation in this study.

Indexed as

GastrectomyEnteral NutritionHumansImmunity, CellularImmunity, HumoralImmunotherapyMalnutritionPostoperative ComplicationsStomach NeoplasmsEnteral immunonutritionEnteral nutritionGastrectomyGastric cancer

Identifiers

PMID29338698
PMCPMC5771223
OpenAlexW2782580842

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.